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  • Primary Antibodies ›
  • TRPM2 Antibodies

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TRPM2 Polyclonal Antibody

1 Reference
View all (30) TRPM2 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Cite TRPM2 Polyclonal Antibody

TRPM2 Polyclonal Antibody

Product Details

OST00483W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-

Immunohistochemistry (IHC)

1:500
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Guinea pig / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 1100-1150 of rat TRPM2 conjugated to blue carrier protein was used as the antigen
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: TRPM2.

Target Information

TRPM2 belongs to the ion transport protein family which includes Sodium, Potassium, Calcium ion channels. This family is characterized by proteins possessing 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. TRPM2 is activated by oxidative stress and confers susceptibility to cell death. Further, TRPM2 is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. Several alternatively spliced transcript variants of the TRPM2 gene have been described, but their full-length nature is not known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: EC 3.6.1.13; EREG 1; KNP 3; Long transient receptor potential channel 2; LTRPC 2; LTrpC-2; MGC133383; null; Transient receptor potential cation channel subfamily M member 2; Transient receptor potential channel 7; transient receptor potential melastatin family 2; transient receptor protein 7; TRPC 7; TrpC7; TRPM 2

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Gene Aliases: 9830168K16Rik; C79133; LTRPC2; Trp7; TRPC7; Trpm2; Trpm2-predicted; Trrp7

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UniProt ID: (Rat) E9PTA2, (Mouse) Q91YD4

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Entrez Gene ID: (Rat) 294329, (Mouse) 28240

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Function(s)
cation channel activity manganese ion transmembrane transporter activity ADP-ribose diphosphatase activity ion channel activity calcium channel activity sodium channel activity hydrolase activity
Process(es)
manganese ion transport metabolic process response to hydroperoxide manganese ion transmembrane transport transport ion transport cation transport sodium ion transport calcium ion transport response to oxidative stress positive regulation of insulin secretion ion transmembrane transport transmembrane transport calcium ion transmembrane transport calcium ion import across plasma membrane positive regulation of oxidative stress-induced neuron death
It has to be done as per old AB suggested Products section.
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