Invitrogen

TRIM27 Polyclonal Antibody

View all (19) TRIM27 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-67533

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:30-1:150
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fusion protein of human TRIM27

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.1 mg/mL

Purification

affinity chromatography

Storage buffer

PBS, pH 7.4, with 40% glycerol

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2688534

Target Information

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Ret finger protein; RFP transforming protein; RING finger protein 76; tripartite motif protein 27; tripartite motif protein TRIM27; tripartite motif-containing 27; Tripartite motif-containing protein 27; Zinc finger protein RFP

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Gene Aliases: AW538890; Gm19403; RFP; RNF76; TRIM27

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UniProt ID: (Human) P14373, (Mouse) Q62158

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Entrez Gene ID: (Human) 5987, (Mouse) 19720

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Function(s)
nucleic acid binding DNA binding transmembrane receptor protein tyrosine kinase activity ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity identical protein binding metal ion binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of adaptive immune response transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of protein kinase activity transport negative regulation of tumor necrosis factor production negative regulation of viral transcription Arp2/3 complex-mediated actin nucleation retrograde transport, endosome to Golgi innate immune response negative regulation of gene expression, epigenetic positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of actin nucleation protein trimerization protein K63-linked ubiquitination interferon-gamma secretion negative regulation of calcium ion import negative regulation of interleukin-2 secretion negative regulation of viral release from host cell spermatogenesis cell proliferation peptidyl-tyrosine phosphorylation
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