Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
TGM2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
15100-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MAEELVLER CDLELETNGR DHHTADLCRE KLVVRRGQPF WLTLHFEGRN YEASVDSLTF SVVTGPAPSQ EAGTKARFPL RDAVEEGDWT ATVVDQQDCT LSLQLTTPAN APIGLYRLSL EASTGYQGSS FVLGHFILLF NAWCPADAVY LDSEEERQEY VLTQQGFIYQ GSAKFIKNIP WNFGQFEDGI LDICLILLDV NPKFLKNAGR DCSRRSSPVY VGRVVSGMVN CNDDQGVLLG RWDNNYGDGV SPMSWIGSVD ILRRWKNHGC QRVKYGQCWV FAAVACTVLR CLGIPTRVVT NYNSAHDQNS NLLIEYFRNE FGEIQGDKSE MIWNFHCWVE SWMTRPDLQP (1-349 aa encoded by BC003551)
Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG
Gene Aliases: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas
UniProt ID: (Human) P21980, (Rat) Q9WVJ6, (Mouse) P21981
Entrez Gene ID: (Human) 7052, (Rat) 56083, (Mouse) 21817
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support