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  • TGF beta-1 Antibodies

Invitrogen

TGF beta-1 Polyclonal Antibody

View all (66) TGF beta-1 antibodies

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Datasheet
Protocols
Questions & Answers

Cite TGF beta-1 Polyclonal Antibody

  • Antibody Testing Data (1)
TGF beta-1 Antibody in Immunocytochemistry (ICC/IF)
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TGF beta-1 Antibody in Immunocytochemistry (ICC/IF)
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TGF beta-1 Antibody (PA5-120329) in ICC/IF

Immunofluorescence analysis of TGF beta-1 in NIH/3T3 cells. Samples were incubated with TGF beta-1 Polyclonal antibody (Product # PA5-120329) using a dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TGF beta-1 Antibody in Immunocytochemistry (ICC/IF)
TGF beta-1 Polyclonal Antibody

Product Details

PA5-120329

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.26 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2913901

Product Specific Information

Positive test controls include: 293T, Mouse lung, Mouse testis, Mouse spleen, Rat lung. The target is usually found in the following locations: Secreted, extracellular matrix, extracellular space.

Immunogen sequence: LSTCKTIDME LVKRKRIEAI RGQILSKLRL ASPPSQGEVP PGPLPEAVLA LYNSTRDRVA GESAEPEPEP EADYYAKEVT RVLMVETHNE IYDKFKQSTH SIYMFFNTSE LREAVPEPVL LSRAELRLLR LKLKVEQHVE LYQKYSNNSW RYLSNRLLAP SDSPEWLSFD VTGVVRQWLS RGGEIEGFRL SAHCSCDSRD NTLQVDINGF TTGRRGDLAT IHGMNRPFLL LMATPLERAQ HLQSSRHRRA L

Target Information

TGF beta-1 (TGFB1, Transforming Growth Factor Beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines, found almost ubiquitously in tissues. Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its pro-domain. Activation of TGF beta-1 requires the binding of aV integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TGF-b binding proteins. Latent forms are complexes of TGF beta-1, an amino-terminal portion of the TGF-beta precursor, designated TGF-LAP (TGF-latency associated peptide), and a specific binding protein, known as LTBP. TGF beta-1 helps regulates proliferation, differentiation, adhesion, migration in many cell types. Many cells have TGF beta receptors, and the protein positively and negatively regulates many other growth factors. TGF beta-1 is cleaved into a latency-associated peptide and a mature TGF beta-1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGF beta-1 homodimer. The mature peptide may also form heterodimers with other TGF beta family members. The gene for TGF beta-1 is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease and cystic fibrosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; TGF beta-1; TGF beta-1 protein; tgf beta1; TGF β; TGF β 1; TGF β1; TGF-B1; TGF-beta 1; TGF-beta 1 protein; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor β1; transforming growth factor, beta-1; transforming growth factor-beta 1

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Gene Aliases: CED; DPD1; LAP; TGF-beta1; TGFB; Tgfb-1; TGFB1; TGFbeta; TGFbeta1

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UniProt ID: (Human) P01137, (Rat) P17246, (Mouse) P04202

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Entrez Gene ID: (Human) 7040, (Rat) 59086, (Mouse) 21803

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Function(s)
glycoprotein binding antigen binding type II transforming growth factor beta receptor binding cytokine activity transforming growth factor beta receptor binding protein binding growth factor activity enzyme binding type I transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding protein homodimerization activity protein serine/threonine kinase activator activity protein heterodimerization activity protein N-terminus binding
Process(es)
protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter MAPK cascade regulation of cell growth ureteric bud development response to hypoxia morphogenesis of a branching structure cell activation epithelial to mesenchymal transition negative regulation of protein phosphorylation positive regulation of protein phosphorylation regulation of sodium ion transport chondrocyte differentiation hematopoietic progenitor cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains tolerance induction to self antigen protein phosphorylation protein export from nucleus ATP biosynthetic process phosphate-containing compound metabolic process cellular calcium ion homeostasis inflammatory response cell cycle arrest mitotic cell cycle checkpoint epidermal growth factor receptor signaling pathway transforming growth factor beta receptor signaling pathway common-partner SMAD protein phosphorylation SMAD protein complex assembly SMAD protein import into nucleus negative regulation of neuroblast proliferation salivary gland morphogenesis endoderm development female pregnancy aging negative regulation of DNA replication cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation germ cell migration response to radiation response to wounding response to glucose defense response to fungus, incompatible interaction response to organic substance positive regulation of gene expression negative regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration positive regulation of peptidyl-threonine phosphorylation positive regulation of pathway-restricted SMAD protein phosphorylation negative regulation of macrophage cytokine production response to organic cyclic compound cell growth regulation of striated muscle tissue development regulation of transforming growth factor beta receptor signaling pathway evasion or tolerance of host defenses by virus negative regulation of cell-cell adhesion hyaluronan catabolic process T cell differentiation negative regulation of ossification negative regulation of cell growth lung development positive regulation of cell migration positive regulation of bone mineralization mammary gland development positive regulation of histone deacetylation organ regeneration positive regulation of protein complex assembly positive regulation of exit from mitosis lipopolysaccharide-mediated signaling pathway positive regulation of cellular protein metabolic process response to estradiol response to progesterone positive regulation of interleukin-17 production receptor catabolic process positive regulation of superoxide anion generation mononuclear cell proliferation positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation response to vitamin D response to laminar fluid shear stress positive regulation of histone acetylation positive regulation of protein dephosphorylation wound healing T cell activation regulation of cell proliferation negative regulation of T cell proliferation regulation of protein import into nucleus positive regulation of protein import into nucleus positive regulation of odontogenesis response to drug myelination myeloid dendritic cell differentiation T cell homeostasis positive regulation of apoptotic process positive regulation of MAP kinase activity regulation of MAPK cascade protein kinase B signaling positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of phosphatidylinositol 3-kinase activity ossification involved in bone remodeling regulatory T cell differentiation cell-cell junction organization negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of isotype switching to IgA isotypes lymph node development digestive tract development negative regulation of skeletal muscle tissue development inner ear development positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of protein secretion negative regulation of phagocytosis negative regulation of immune response negative regulation of T cell activation positive regulation of chemotaxis positive regulation of NF-kappaB transcription factor activity regulation of binding regulation of DNA binding positive regulation of smooth muscle cell differentiation negative regulation of release of sequestered calcium ion into cytosol positive regulation of protein kinase B signaling face morphogenesis frontal suture morphogenesis pathway-restricted SMAD protein phosphorylation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction mammary gland branching involved in thelarche branch elongation involved in mammary gland duct branching regulation of branching involved in mammary gland duct morphogenesis negative regulation of gene silencing by miRNA regulation of cartilage development lens fiber cell differentiation response to cholesterol positive regulation of cell cycle arrest cellular response to growth factor stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus extracellular matrix assembly positive regulation of branching involved in ureteric bud morphogenesis extrinsic apoptotic signaling pathway negative regulation of hyaluronan biosynthetic process positive regulation of protein localization to nucleus positive regulation of NAD+ ADP-ribosyltransferase activity regulation of actin cytoskeleton reorganization regulation of miRNA metabolic process positive regulation of transcription regulatory region DNA binding connective tissue replacement involved in inflammatory response wound healing platelet degranulation Notch signaling pathway positive regulation of vascular endothelial growth factor production negative regulation of extracellular matrix disassembly macrophage derived foam cell differentiation oligodendrocyte development cell migration regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of interleukin-23 production negative regulation of interleukin-17 production regulation of apoptotic process positive regulation of vascular permeability positive regulation of regulatory T cell differentiation negative regulation of cell differentiation active induction of host immune response by virus positive regulation of fibroblast proliferation positive regulation of peptidyl-tyrosine phosphorylation positive regulation of cell division regulation of blood vessel remodeling regulation of SMAD protein import into nucleus positive regulation of extracellular matrix assembly positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of protein localization to plasma membrane negative regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of receptor clustering regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of cardiac muscle cell differentiation skeletal system development CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment defense response skeletal muscle tissue development organ morphogenesis regulation of gene expression regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation growth cell development T-helper 17 cell lineage commitment
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