NeoBiotechnologies

TFAP2A Monoclonal Antibody (PCRP-TFAP2A-2C2)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
TFAP2A Monoclonal Antibody (PCRP-TFAP2A-2C2)

Product Details

7020-MSM2-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

PCRP-TFAP2A-2C2

Immunogen

Recombinant full-length human TFAP2A protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Dry ice (international)

Product Specific Information

Positive Control:Human skin or placenta. HeLa cells.

Cellular Location: Nucleus.

Target Information

TFAP2A is a sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limbs and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. TFAP2A is the only AP-2 protein required for early morphogenesis of the lens vesicle.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; ERF-1; FLJ51761; OTTHUMP00000214240; OTTHUMP00000214243; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha

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Gene Aliases: AP-2; AP-2alpha; AP2TF; BOFS; TFAP2; TFAP2A

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UniProt ID: (Human) P05549

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Entrez Gene ID: (Human) 7020

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription coactivator activity protein binding transcription factor binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding protein dimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development optic vesicle morphogenesis optic cup structural organization transcription from RNA polymerase II promoter sensory perception of sound negative regulation of cell proliferation response to water deprivation positive regulation of gene expression retina layer formation negative regulation of transcription by competitive promoter binding Schwann cell development trigeminal nerve development oculomotor nerve formation positive regulation of bone mineralization response to lipopolysaccharide embryonic forelimb morphogenesis inner ear morphogenesis negative regulation of apoptotic process positive regulation of neuron apoptotic process regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic cranial skeleton morphogenesis palate development bone morphogenesis eyelid development in camera-type eye positive regulation of tooth mineralization cellular response to iron ion negative regulation of reactive oxygen species metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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