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Invitrogen
TBX3 Polyclonal Antibody
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FIGURE: 1 / 31
TBX3 Antibody (42-4800) in IHC (P)
Product Details
42-4800
Species Reactivity
Published species
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Product Specific Information
42-4800 has been successfully used in immunohistochemistry analysis of Tbx3 in mouse E16.5 frozen lung sections.
Target Information
T-box 3 (TBX3) is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. The Tbx3 protein is a transcriptional repressor that binds the canonical Brachychury bindig sites, and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Tbx3 is required for normal mammary development and is also implicated in tumor development. Tbx3 expression also increases during osteoblast differentiation, and may function as a determinant of osteoblast cell numbers. Mutations in T-box 3 cause ulnar-mammary syndrome (MIM 181450), affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing results in three transcript variants encoding different isoforms; however, the nature of one full length variant has not been determined. Subsets of human breast cancer cell lines overexpress TBX36. in vitro, Tbx3 overexpression in mouse embryo fibroblasts leads to immortalization of cells. Truncated forms of Tbx3 are increased in plasma samples.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bladder cancer related protein XHL; T-box 3 (ulnar mammary syndrome); T-box protein 3; T-box transcription factor TBX3
Gene Aliases: D5Ertd189e; TBX3; TBX3-ISO; UMS; XHL
UniProt ID: (Human) O15119, (Mouse) P70324, (Rat) Q7TST9
Entrez Gene ID: (Human) 6926, (Mouse) 21386, (Rat) 353305
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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