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Proteintech
TBX21/T-bet Polyclonal Antibody
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Product Details
13700-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MGIVEPGCG DMLTGTEPMP GSDEGRAPGA DPQHRYFYPE PGAQDADERR GGGSLGSPYP GGALVPAPPS RFLGAYAYPP RPQAAGFPGA GESFPPPADA EGYQPGEGYA APDPRAGLYP GPREDYALPA GLEVSGKLRV ALNNHLLWSK FNQHQTEMII TKQGRRMFPF LSFTVAGLEP TSHYRMFVDV VLVDQHHWRY QSGKWVQCGK AEGSMPGNRL YVHPDSPNTG AHWMRQEVSF GKLKLTNNKG ASNNVTQMIV LQSLHKYQPR LHIVEVNDGE PEAACNASNT HIFTFQETQF IAVTAYQNAE ITQLKIDNNP FAKGFRENF (1-328 aa encoded by BC039739 )
Target Information
T-bet, also known as TBX21, is a T-cell specific transcription factor containing a single T-box DNA-binding domain. It controls the expression of the TH1 cytokine, interferon-gamma. Both Th1 and Th17 cells are crucial in immune regulation and autoimmune disease development. T-bet initiates Th1 lineage development from naive Th precursor cells and directs T cell differentiation to Th1 versus Th17. T-bet is cooperating with Stat4 (signal tranducer and activator of transcription 4) in programming chromatin architecture for Th1 gene expression. Genetic variations in T-bet are associated with susceptibility to aspirin-induced asthma and nasal polyps.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:11599; T-box expressed in T cells; T-box protein 21; T-box transcription factor TBX21; T-cell-specific T-box transcription factor T-bet; Transcription factor TBLYM
Gene Aliases: T-bet; T-PET; TBET; TBLYM; TBT1; TBX21
UniProt ID: (Human) Q9UL17, (Mouse) Q9JKD8
Entrez Gene ID: (Human) 30009, (Mouse) 57765
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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