Invitrogen

TACR1 Polyclonal Antibody

3 References
View all (16) TACR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
TACR1 Polyclonal Antibody

Product Details

PA3-301

Applications
Tested Dilution
Publications

Western Blot (WB)

1:5,000
-

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:1,000
-

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues S(387) S R S D S K T M T E S F S F S S N V L S(407) of human NK1 receptor protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2200607

Product Specific Information

PA3-301 detects neurokinin-1 receptor in human samples.

PA3-301 has been successfully used in Western blot and immunohistochemistry (paraffin) procedures.

The PA3-301 immunogen is a synthetic peptide corresponding to residues S(387) S R S D S K T M T E S F S F S S N V L S(407) of human NK1 receptor protein.

Target Information

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: NK-1 receptor; NK-1R; SPR; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1

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UniProt ID: (Human) P25103

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Entrez Gene ID: (Human) 6869

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Function(s)
tachykinin receptor activity protein binding substance P receptor activity
Process(es)
aggressive behavior acute inflammatory response positive regulation of leukocyte migration angiotensin-mediated drinking behavior inflammatory response cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway chemical synaptic transmission long-term memory associative learning response to heat detection of abiotic stimulus response to ozone positive regulation of epithelial cell migration response to auditory stimulus regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to estradiol response to progesterone response to nicotine operant conditioning positive regulation of renal sodium excretion sperm ejaculation eating behavior positive regulation of vascular permeability response to morphine response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of saliva secretion positive regulation of hormone secretion behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly response to electrical stimulus smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction
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