Invitrogen

Syntaxin 1 Recombinant Rabbit Monoclonal Antibody (JE54-37)

Name: Syntaxin 1 Recombinant Rabbit Monoclonal Antibody (JE54-37)
Brand: Invitrogen
SKU: MA5-36185

View all (31) Syntaxin 1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (6)

Syntaxin 1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 6

Syntaxin 1 Antibody (MA5-36185) in IHC (P)

Immunohistochemical analysis of Syntaxin 1 in paraffin-embedded human pancreas tissue using a monoclonal antibody (Product #MA5-36185). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:200) for 30 mi... View More

Syntaxin 1 Antibody in Western Blot (WB)

Syntaxin 1 Antibody in Flow Cytometry (Flow)

Product Image Gallery

Immunogen image

Immunogen Image Syntaxin 1 Recombinant Rabbit Monoclonal Antibody (JE54-37)

Product Details

MA5-36185

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Flow Cytometry (Flow)

Assay-dependent

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

JE54-37

Immunogen

Synthetic peptide within Human Syntaxin 1a aa 1-50

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2890508

Target Information

Syntaxin 1 is a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?

Let us know so we can reference it here.

Cite this product

Bioinformatics

Protein Aliases: Neuron-specific antigen HPC-1; P35A; STX1B; STX1B1; STX1B2; STXA1; Synaptotagmin-associated 35 kDa protein; syntaxin 1 a; syntaxin 1A (brain); syntaxin 1A (brain)-like; Syntaxin-1A; Syntaxin-1B1; Syntaxin-1B2

View more View less

Gene Aliases: HPC-1; P35-1; Sap; STX1; STX1A; SYN1A

View more View less

UniProt ID: (Human) Q16623, (Mouse) O35526, (Rat) P32851

View more View less

Entrez Gene ID: (Human) 6804, (Mouse) 20907, (Rat) 116470

View more View less

Function(s)

SNARE binding glycoprotein binding SNAP receptor activity protein binding myosin binding calcium channel inhibitor activity chloride channel inhibitor activity kinase binding protein domain specific binding protein binding, bridging myosin head/neck binding ATP-dependent protein binding ion channel binding protein heterodimerization activity protein N-terminus binding calcium-dependent protein binding

Process(es)

positive regulation of neurotransmitter secretion transport neurotransmitter transport intracellular protein transport exocytosis response to gravity positive regulation of norepinephrine secretion regulation of synaptic vesicle priming vesicle-mediated transport calcium ion regulated exocytosis regulation of exocytosis synaptic vesicle fusion to presynaptic active zone membrane secretion by cell positive regulation of catecholamine secretion positive regulation of exocytosis positive regulation of calcium ion-dependent exocytosis vesicle docking positive regulation of excitatory postsynaptic potential neurotransmitter secretion glutamate secretion synaptic vesicle docking regulation of insulin secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

Syntaxin 1 Recombinant Rabbit Monoclonal Antibody (JE54-37)

Syntaxin 1 Antibody (MA5-36185) in IHC (P)

Product Details

MA5-36185

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Flow Cytometry (Flow)

Species Reactivity

Host/Isotype

Expression System

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

References (0)

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!