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NeoBiotechnologies
Spectrin beta III (SPTBN2) Monoclonal Antibody (SPTBN2, 1582)
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Product Details
6712-MSM2-P1
Species Reactivity
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Type
Clone
Immunogen
Conjugate
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Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Beta-III spectrin; glutamate transporter EAAT4-associated protein 41; Spectrin Beta; spectrin beta chain, brain 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; Spinocerebellar ataxia 5 protein
Gene Aliases: GTRAP41; KIAA0302; SCA5; SCAR14; SPTBN2
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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