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SorLA Polyclonal Antibody

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View all (20) SORL1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
SorLA Polyclonal Antibody

Product Details

OSS00091G-500UG

Applications
Tested Dilution
Publications

Western Blot (WB)

10-50 µg/mL
-

Immunohistochemistry (IHC)

10-50 µg/mL
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from c-terminal of mouse SorLA conjugated to blue carrier protein was used as the antigen
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Purification

Ammonium sulfate precipitation

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: SORLA.

Target Information

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ21930; FLJ39258; Gp250; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mSorLA; SorLA-1; Sortilin-related receptor; Sorting protein-related receptor containing LDLR class A repeats

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Gene Aliases: 2900010L19Rik; AI596264; AW261561; gp250; LR11; mSorLA; Sorl1; SorLA

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UniProt ID: (Mouse) O88307

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Entrez Gene ID: (Mouse) 20660

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Function(s)
beta-amyloid binding protein binding low-density lipoprotein particle binding ADP-ribosylation factor binding
Process(es)
protein targeting to Golgi protein targeting protein targeting to lysosome lipid metabolic process transport lipid transport post-Golgi vesicle-mediated transport endocytosis multicellular organism development steroid metabolic process cholesterol metabolic process regulation of smooth muscle cell migration cell migration negative regulation of protein binding negative regulation of protein oligomerization negative regulation of MAP kinase activity protein retention in Golgi apparatus positive regulation of protein catabolic process negative regulation of neurogenesis protein maturation positive regulation of protein exit from endoplasmic reticulum negative regulation of neuron death negative regulation of beta-amyloid formation positive regulation of choline O-acetyltransferase activity negative regulation of tau-protein kinase activity positive regulation of ER to Golgi vesicle-mediated transport positive regulation of early endosome to recycling endosome transport negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of protein localization to early endosome negative regulation of neurofibrillary tangle assembly positive regulation of endocytic recycling
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