Invitrogen

STING Polyclonal Antibody

Name: STING Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-116052

View all (93) STING antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (3)

STING Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 3

STING Antibody (PA5-116052) in ICC/IF

Immunocytochemistry analysis of STING in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116052) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).

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Immunogen image

Immunogen Image STING Polyclonal Antibody

Product Details

PA5-116052

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:50-1:200

Immunocytochemistry (ICC/IF)

1:100-1:500

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TMEM173(Accession Q86WV6), corresponding to amino acid residues S241-F291.

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2900686

Product Specific Information

Antibody detects endogenous levels of total TMEM173/STING.

Target Information

STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; mSTING; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; rSTING; Stimulator of interferon genes protein; tm173; Transmembrane protein 173

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Gene Aliases: 2610307O08Rik; ERIS; hMITA; hSTING; MITA; MPYS; NET23; RGD1562552; SAVI; STING; STING1; TMEM173

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UniProt ID: (Human) Q86WV6, (Mouse) Q3TBT3, (Rat) F1M391

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Entrez Gene ID: (Human) 340061, (Mouse) 72512, (Rat) 498840

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Function(s)

protein binding transcription factor binding protein kinase binding ubiquitin protein ligase binding cyclic-di-GMP binding identical protein binding protein homodimerization activity cyclic-GMP-AMP binding nucleotide binding

Process(es)

activation of innate immune response positive regulation of defense response to virus by host apoptotic process positive regulation of protein binding regulation of type I interferon production positive regulation of type I interferon production interferon-beta production positive regulation of protein import into nucleus, translocation cellular response to interferon-beta positive regulation of transcription factor import into nucleus innate immune response positive regulation of transcription from RNA polymerase II promoter defense response to virus cellular response to exogenous dsRNA cellular response to organic cyclic compound immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STING Polyclonal Antibody

STING Antibody (PA5-116052) in ICC/IF

Product Details

PA5-116052

Western Blot (WB)

Immunohistochemistry (PFA fixed) (IHC (PFA))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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