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Invitrogen
STIM1 Monoclonal Antibody (CDN3H4)
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FIGURE: 1 / 9
STIM1 Antibody (MA1-19451) in ICC/IF
Product Details
MA1-19451
Species Reactivity
Published species
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Conjugate
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Product Specific Information
This antibody reacts with a cytoplasmic epitope of human and rodent STIM1, a 84 kDa essential and conserved regulator of store-operated Ca2+ channel function.
Western Blot: Both reducing and non-reducing conditions; Immunocytochemistry: Methanol-acetone fixation.
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: stim1 {ECO:0000312|RGD:1306831}; STIM1L; Stromal interaction molecule 1
Gene Aliases: D11S4896E; GOK; IMD10; SIM; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586, (Mouse) P70302, (Rat) P84903
Entrez Gene ID: (Human) 6786, (Mouse) 20866, (Rat) 361618
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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