NeoBiotechnologies

STAT5B Monoclonal Antibody (STAT5B, 2611)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
STAT5B Monoclonal Antibody (STAT5B, 2611)

Product Details

6777-MSM1-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

STAT5B, 2611

Immunogen

Recombinant full-length human STAT5B protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Signal transducer and activator of transcription 5B; STA5B; STAT; transcription factor STAT5B

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Gene Aliases: STAT5; STAT5B

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UniProt ID: (Human) P51692

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Entrez Gene ID: (Human) 6777

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein tyrosine kinase activity signal transducer activity protein binding protein phosphatase binding glucocorticoid receptor binding protein dimerization activity
Process(es)
allantoin metabolic process luteinization response to hypoxia natural killer cell differentiation liver development citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process acute-phase response JAK-STAT cascade female pregnancy lactation peptidyl-tyrosine phosphorylation regulation of steroid metabolic process taurine metabolic process lipid storage regulation of epithelial cell differentiation response to estradiol response to lipopolysaccharide positive regulation of natural killer cell proliferation positive regulation of natural killer cell differentiation cellular response to hormone stimulus T cell differentiation in thymus prolactin signaling pathway regulation of multicellular organism growth positive regulation of multicellular organism growth positive regulation of activated T cell proliferation progesterone metabolic process T cell homeostasis negative regulation of apoptotic process positive regulation of interleukin-2 biosynthetic process response to ethanol positive regulation of B cell differentiation positive regulation of gamma-delta T cell differentiation negative regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter positive regulation of natural killer cell mediated cytotoxicity creatinine metabolic process development of secondary female sexual characteristics development of secondary male sexual characteristics Peyer's patch development positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of cellular component movement JAK-STAT cascade involved in growth hormone signaling pathway response to interleukin-2 response to interleukin-4 response to interleukin-15 cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus mast cell migration
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