Invitrogen

STAR Recombinant Rabbit Monoclonal Antibody (HL1360)

View all (31) STAR antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-47013

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1360

Immunogen

Recombinant protein encompassing a sequence within the center region of human StAR. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2938085

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

Steroidogenic acute regulatory protein (StAR) plays a significant role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein capable of facilitating cholesterol metabolism into pregnenolone. StAR is prevalently expressed in mitochondria of steroid-producing adrenal and gonadal tissue. Abnormalities in StAR gene expression are impacted in autosomal Lipoid Congenial Adrenal Hyperplasia (LCAH) resulting in defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR has yet to be elucidated.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cholesterol trafficker; Luteinizing hormone-induced protein; mitochondrial steroid acute regulatory protein; StAR; StAR related lipid transfer (START) domain containing 1; StAR-related lipid transfer (START) domain containing 1; StARD1; START domain containing 1; START domain-containing protein 1; steroid acute regulatory protein; steroidogenic acute regulator; Steroidogenic acute regulatory protein, mitochondrial; testis secretory sperm-binding protein Li 241mP

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Gene Aliases: AV363654; D8Ertd419e; STAR; STARD1

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UniProt ID: (Human) P49675, (Mouse) P51557

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Entrez Gene ID: (Human) 6770, (Mouse) 20845

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Function(s)
protein binding cholesterol binding cholesterol transporter activity lipid binding
Process(es)
steroid biosynthetic process bile acid biosynthetic process estrogen biosynthetic process transport lipid transport glucocorticoid metabolic process positive regulation of gene expression cellular response to interferon-alpha negative regulation of neuron apoptotic process cellular lipid metabolic process regulation of neuronal synaptic plasticity positive regulation of neurogenesis regulation of steroid biosynthetic process C21-steroid hormone biosynthetic process progesterone biosynthetic process brain development response to nutrient cholesterol metabolic process male gonad development response to herbicide response to ionizing radiation response to lead ion response to activity diterpenoid metabolic process insecticide metabolic process biphenyl metabolic process dibenzo-p-dioxin metabolic process phenol-containing compound metabolic process phthalate metabolic process intracellular cholesterol transport cellular response to insulin stimulus response to nicotine response to drug response to hydrogen peroxide circadian sleep/wake cycle, REM sleep response to estrogen response to leptin cellular response to fibroblast growth factor stimulus response to ethanol response to corticosterone response to fungicide testosterone biosynthetic process positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide cellular response to antibiotic cellular response to cadmium ion cellular response to alkaloid cellular response to cAMP cellular response to glucose stimulus cellular response to interferon-gamma cellular response to follicle-stimulating hormone stimulus cellular response to luteinizing hormone stimulus cellular response to growth hormone stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus cellular response to epinephrine stimulus
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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