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Invitrogen
SQLE Polyclonal Antibody
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Product Details
PA5-96127
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
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RRID
Product Specific Information
Positive Samples: SKOV3, Mouse liver, Mouse kidney, Rat liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane, Multi-pass membrane protein
Immunogen sequence: VSVSSHFVGF LMKNAPQFKA NHAELILANP SPVLIYQISS SETRVLVDIR GEMPRNLREY MVEKIYPQIP DHLKEPFLEA TDNSHLRSMP ASFLPPSSVK K
Target Information
SQLE, also named as ERG1, SE and SM, belongs to the squalene monooxygenase family. It catalyzes the first oxygenation step in cholesterol synthesis, acting on squalene before cyclization into the basic steroid structure. SQLE may serve as a flux-controlling enzyme beyond 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR, considered as rate limiting). It is also post translationally regulated by cholesterol-dependent proteasomal degradation. The MW of SQLE is about 64 kDa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLJ30795; SE; Squalene epoxidase; Squalene monooxygenase
Gene Aliases: AI323792; ERG1; SQLE
UniProt ID: (Human) Q14534, (Mouse) P52019, (Rat) P52020
Entrez Gene ID: (Human) 6713, (Mouse) 20775, (Rat) 29230
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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