AbboMax

SOX-2 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
SOX-2 Polyclonal Antibody

Product Details

601-490

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-

Immunocytochemistry (ICC/IF)

1:250
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide derived from N-terminus of Human SOX-2 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive control: Mouse embryonic brain

Cellular location: Nuclear.

Target Information

SOX2 is an intronless gene encoding a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of the SOX2 gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. The SOX2 gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). Further, SOX2 protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation, optic nerve hypoplasia and syndromic microphthalmia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cSox2; Delta EF2a; MCOPS3 (Microphthalmia Syndromic type 3); sex determining region Y-box 2; SOX 2; Sox2 transcription factor; SRY (sex determining region Y) box 2; SRY (sex determining region Y)-box 2; SRY box 2; SRY related HMG box 2; SRY-box 2; SRY-box containing gene 2; SRY-related HMG-box 2; SRY-related HMG-box gene 2; Transcription factor SOX-2; transcription factor SOX2

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Gene Aliases: ANOP3; BOS_1007; lcc; MCOPS3; RGD1565646; Sox-2; SOX2; ysb

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UniProt ID: (Chicken) P48430, (Human) P48431, (Mouse) P48432

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Entrez Gene ID: (Chicken) 396105, (Bovine) 784383, (Human) 6657, (Dog) 488092, (Rat) 499593, (Mouse) 20674

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Function(s)
transcription factor activity, sequence-specific DNA binding miRNA binding sequence-specific DNA binding transcription regulatory region DNA binding transcription regulatory region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding RNA polymerase II transcription factor activity, sequence-specific DNA binding molecular_function chromatin binding transcription factor binding protein heterodimerization activity chromatin DNA binding
Process(es)
osteoblast differentiation eye development endodermal cell fate specification transcription, DNA-templated cell cycle arrest response to wounding pituitary gland development somatic stem cell population maintenance regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter inner ear development negative regulation of epithelial cell proliferation response to growth factor negative regulation of canonical Wnt signaling pathway negative regulation of transcription from RNA polymerase II promoter chromatin organization regulation of transcription, DNA-templated transcription from RNA polymerase II promoter regulation of gene expression glial cell fate commitment adenohypophysis development positive regulation of cell-cell adhesion forebrain development tissue regeneration positive regulation of cell differentiation neuronal stem cell population maintenance cell fate specification positive regulation of neuroblast proliferation regulation of transcription from RNA polymerase II promoter sensory perception of sound response to organic substance stem cell population maintenance forebrain neuron differentiation cerebral cortex development negative regulation of Wnt signaling pathway male genitalia development positive regulation of epithelial cell differentiation olfactory placode formation response to retinoic acid inner ear morphogenesis tongue development cell fate commitment negative regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation positive regulation of Notch signaling pathway pigment biosynthetic process lung alveolus development embryonic organ development anatomical structure formation involved in morphogenesis neuron fate commitment diencephalon morphogenesis stem cell differentiation regulation of neurogenesis detection of mechanical stimulus involved in sensory perception of sound detection of mechanical stimulus involved in equilibrioception retina morphogenesis in camera-type eye lens induction in camera-type eye epithelial tube branching involved in lung morphogenesis multicellular organism development
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