OriGene

SORL1 Monoclonal Antibody (OTI2D5), TrueMAB™

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers
SORL1 Monoclonal Antibody (OTI2D5), TrueMAB™

Product Details

CF811229

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

OTI2D5

Immunogen

Human recombinant protein fragment corresponding to amino acids 573-753 of human SORL1 produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ21930; FLJ39258; Gp250; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mosaic protein LR11; mSorLA; SorLA; SorLA-1; Sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; Sorting protein-related receptor containing LDLR class A repeats

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Gene Aliases: 2900010L19Rik; AI596264; AW261561; C11orf32; gp250; LR11; LRP9; mSorLA; RGD619914; SORL1; SORLA; SorLA-1

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UniProt ID: (Human) Q92673, (Rat) P0DSP1, (Mouse) O88307

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Entrez Gene ID: (Human) 6653, (Rat) 300652, (Mouse) 20660

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Function(s)
beta-amyloid binding transmembrane signaling receptor activity protein binding low-density lipoprotein particle binding ADP-ribosylation factor binding
Process(es)
protein targeting to Golgi protein targeting protein targeting to lysosome lipid transport post-Golgi vesicle-mediated transport receptor-mediated endocytosis signal transduction cholesterol metabolic process regulation of smooth muscle cell migration negative regulation of protein binding negative regulation of protein oligomerization negative regulation of MAP kinase activity protein retention in Golgi apparatus positive regulation of protein catabolic process negative regulation of neurogenesis protein maturation positive regulation of protein exit from endoplasmic reticulum negative regulation of neuron death negative regulation of beta-amyloid formation positive regulation of choline O-acetyltransferase activity negative regulation of tau-protein kinase activity positive regulation of ER to Golgi vesicle-mediated transport positive regulation of early endosome to recycling endosome transport negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process positive regulation of protein localization to early endosome negative regulation of neurofibrillary tangle assembly positive regulation of endocytic recycling cell proliferation cell migration lipid metabolic process transport endocytosis multicellular organism development steroid metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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