Invitrogen

SOD1 Polyclonal Antibody

Advanced Verification
5 Published Figures
12 References
View all (76) SOD1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
SOD1 Polyclonal Antibody

Product Details

PA5-27240

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:10,000
View 9 publications 9 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Frozen) (IHC (F))

Assay-dependent
View 1 publication 1 publication

ChIP assay (ChIP)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SOD1. The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544716

Product Specific Information

Recommended positive controls: 293T, A431, HeLa, HepG2, NT2D1, PC-3, SK-N-SH, Rat brain, U87-MG.

Predicted reactivity: Mouse (100%), Rat (100%), Chimpanzee (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SOD1 (superoxide dismutase) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. This isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Amyotrophic lateral sclerosis 1 (ALS1); Cu(2+)-Zn2+ superoxide dismutase; Cu/Zn SOD; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HGNC:11179; hSod1; indophenoloxidase A; Indophenoloxidase A (IPOA); SOD, soluble; superoxide dismutase; Superoxide dismutase 1; Superoxide Dismutase 1 (SOD1); Superoxide dismutase [Cu-Zn]; superoxide dismutase, cystolic

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Gene Aliases: ALS; ALS1; B430204E11Rik; Cu/Zn-SOD; CuZnSOD; HEL-S-44; homodimer; hSod1; Ipo-1; Ipo1; IPOA; SOD; Sod-1; SOD1; SODC

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UniProt ID: (Human) P00441, (Mouse) P08228, (Rat) P07632

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Entrez Gene ID: (Human) 6647, (Mouse) 20655, (Rat) 24786

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Function(s)
superoxide dismutase activity copper ion binding protein binding zinc ion binding protein phosphatase 2B binding identical protein binding protein homodimerization activity Rac GTPase binding chaperone binding antioxidant activity oxidoreductase activity enzyme binding metal ion binding
Process(es)
activation of MAPK activity response to reactive oxygen species response to superoxide ovarian follicle development positive regulation of cytokine production retina homeostasis myeloid cell homeostasis glutathione metabolic process superoxide metabolic process cellular iron ion homeostasis response to oxidative stress spermatogenesis embryo implantation aging cell aging sensory perception of sound locomotory behavior anterograde axonal transport retrograde axonal transport regulation of blood pressure response to heat response to organic substance transmission of nerve impulse removal of superoxide radicals response to nutrient levels peripheral nervous system myelin maintenance positive regulation of superoxide anion generation regulation of multicellular organism growth response to drug response to hydrogen peroxide superoxide anion generation negative regulation of apoptotic process positive regulation of catalytic activity regulation of GTPase activity negative regulation of neuron apoptotic process response to ethanol negative regulation of cholesterol biosynthetic process regulation of protein kinase activity response to copper ion muscle cell cellular homeostasis response to axon injury hydrogen peroxide biosynthetic process regulation of mitochondrial membrane potential oxidation-reduction process heart contraction neurofilament cytoskeleton organization relaxation of vascular smooth muscle auditory receptor cell stereocilium organization reactive oxygen species metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway response to amphetamine double-strand break repair apoptotic DNA fragmentation response to carbon monoxide cellular response to oxidative stress cellular response to potassium ion response to antibiotic cellular response to cadmium ion cellular response to ATP response to antipsychotic drug placenta development platelet degranulation regulation of T cell differentiation in thymus positive regulation of apoptotic process regulation of organ growth thymus development
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