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  • SLC12A6 Antibodies

Invitrogen

SLC12A6 Polyclonal Antibody

View all (8) SLC12A6 antibodies

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Datasheet
Protocols
Questions & Answers

Cite SLC12A6 Polyclonal Antibody

  • Antibody Testing Data (2)
SLC12A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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SLC12A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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SLC12A6 Antibody (PA5-80005) in IHC (P)

Immunohistochemistry analysis of SLC12A6 in paraffin-embedded section of human colorectal adenocarcinoma tissue. Samples were incubated with SLC12A6 polyclonal antibody (Product # PA5-80005) using a dilution of 2 μg/mL overnight at 4°C followed by Peroxidase Conjugated Goat Anti-rabbit IgG incubated for 30 minutes at 37°C. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retriev... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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SLC12A6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
SLC12A6 Antibody in Western Blot (WB)
SLC12A6 Polyclonal Antibody

Product Details

PA5-80005

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC12A6 (1060-1080aa QKAKSMEGFQDLLNMRPDQSN).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747120

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat brain tissue, rat C6 whole cell, mouse brain tissue. IHC: human colorectal adenocarcinomar tissue.

Target Information

SLC12A6 is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DKFZP434D2135; Electroneutral potassium-chloride cotransporter 3; furosemide-sensitive KCl cotransporter 3; K-Cl cotransporter 3; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; solute carrier family 12 (potassium/chloride transporter), member 6; solute carrier family 12 (potassium/chloride transporters), member 6; Solute carrier family 12 member 6

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Gene Aliases: 9530023I19Rik; ACCPN; gaxp; KCC3; KCC3A; KCC3B; SLC12A6

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UniProt ID: (Human) Q9UHW9, (Mouse) Q924N4

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Entrez Gene ID: (Human) 9990, (Mouse) 107723, (Rat) 691209

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Function(s)
potassium:chloride symporter activity potassium ion symporter activity protein binding potassium ion transmembrane transporter activity protein kinase binding rubidium ion transmembrane transporter activity
Process(es)
angiogenesis ion transport chemical synaptic transmission cellular hypotonic salinity response potassium ion transmembrane transport chloride transmembrane transport potassium ion import rubidium ion transport cellular hypotonic response
It has to be done as per old AB suggested Products section.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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