Invitrogen

SLC11A1 Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
SLC11A1 Polyclonal Antibody

Product Details

PA5-114373

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

2 µg/mL
-

ELISA (ELISA)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human NRAMP1/SLC11A1 recombinant protein (Position: F183-S549).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 4mg trehalose

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2884829

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human K562 whole cell, human THP-1 whole cell, human placenta tissue, human A549 whole cell, human Caco-2 whole cell, human HepG2 whole cell, human U2OS whole cell, human Hela whole cell. IHC: human intestinal cancer tissue, mouse spleen tissue, rat spleen tissue. ICC/IF: MCF-7 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Information

NRAMP1, also known as SLC11A1, is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as leprosy and tuberculosis, and inflammatory diseases such as Crohn disease and rheumatoid arthritis. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: host resistance locus Bcg/Ity/Lsh; natural resistance associated macrophage protein 1; Natural resistance-associated macrophage protein 1; NRAMP 1; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1; solute carrier family 11 (sodium/phosphate symporters), member 1; Solute carrier family 11 member 1

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Gene Aliases: Bcg; Itg; Ity; LSH; NRAMP; NRAMP1; SLC11A1

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UniProt ID: (Human) P49279, (Mouse) P41251, (Rat) P70553

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Entrez Gene ID: (Human) 6556, (Mouse) 18173, (Rat) 316519

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Function(s)
manganese ion transmembrane transporter activity protein homodimerization activity transition metal ion transmembrane transporter activity metal ion:proton antiporter activity transporter activity molecular_function
Process(es)
protein import into nucleus, translocation MAPK cascade negative regulation of cytokine production positive regulation of cytokine production T cell proliferation involved in immune response T cell cytokine production positive regulation of dendritic cell antigen processing and presentation positive regulation of T-helper 1 type immune response transport ion transport iron ion transport manganese ion transport cellular cadmium ion homeostasis cellular iron ion homeostasis phagocytosis inflammatory response vacuolar acidification response to bacterium positive regulation of gene expression nitrite transport activation of protein kinase activity response to lipopolysaccharide interleukin-2 production interleukin-3 production positive regulation of interferon-gamma production response to interferon-gamma wound healing macrophage activation defense response to bacterium defense response to protozoan L-arginine import MHC class II biosynthetic process respiratory burst positive regulation of transcription from RNA polymerase II promoter antigen processing and presentation of peptide antigen mRNA stabilization positive regulation of phagocytosis defense response to Gram-negative bacterium iron ion homeostasis multicellular organismal iron ion homeostasis cadmium ion transmembrane transport divalent metal ion export manganese ion transmembrane transport hydrogen ion transmembrane transport cell redox homeostasis biological_process
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