Invitrogen

SHP2 Polyclonal Antibody

2 Published Figures
2 References
View all (57) SHP2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-27312

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of human SHP2. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.63 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2544788

Product Specific Information

Recommended positive controls: 293T, HeLa, mouse brain, rat brain.

Predicted reactivity: Mouse (98%), Rat (98%), Xenopus laevis (95%), Chicken (98%), Rhesus Monkey (100%), Bovine (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: encodes catalytic domain; HCP; HGNC:9644; MGC14433; Noonan syndrome 1; null; OTTHUMP00000166108; protein tyrosine phosphatase SH-PTP2; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase SYP; PTP-1D; PTP-2C; PTP1C; SH-PTP2; SH-PTP2 protein tyrosine phosphatase non-receptor type 11; SH-PTP2 protein tyrosine phosphatase, non-receptor type 11; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase-2; SHP-2; Tyrosine-protein phosphatase non-receptor type 11

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Gene Aliases: 2700084A17Rik; AW536184; BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP1D; PTP2C; PTPN11; SAP-2; SH-PTP2; SH-PTP3; SHP-2; SHP2; SHPTP2; Syp

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UniProt ID: (Human) Q06124, (Mouse) P35235, (Rat) P41499

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Entrez Gene ID: (Human) 5781, (Mouse) 19247, (Rat) 25622

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Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity SH3/SH2 adaptor activity insulin receptor binding protein binding 1-phosphatidylinositol-3-kinase activity protein domain specific binding receptor tyrosine kinase binding D1 dopamine receptor binding phospholipase binding insulin receptor substrate binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity peptide hormone receptor binding hydrolase activity phosphatase activity
Process(es)
DNA damage checkpoint activation of MAPK activity protein dephosphorylation lipid metabolic process triglyceride metabolic process epidermal growth factor receptor signaling pathway integrin-mediated signaling pathway axonogenesis brain development heart development hormone-mediated signaling pathway positive regulation of signal transduction dephosphorylation platelet formation microvillus organization abortive mitotic cell cycle regulation of cell adhesion mediated by integrin negative regulation of cell adhesion mediated by integrin multicellular organism growth organ growth peptidyl-tyrosine dephosphorylation megakaryocyte development atrioventricular canal development ERBB signaling pathway regulation of multicellular organism growth hormone metabolic process glucose homeostasis positive regulation of mitotic cell cycle negative regulation of insulin secretion regulation of protein export from nucleus positive regulation of hormone secretion negative regulation of hormone secretion platelet-derived growth factor receptor signaling pathway neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway multicellular organismal reproductive process genitalia development inner ear development homeostasis of number of cells within a tissue negative regulation of cortisol secretion negative regulation of growth hormone secretion face morphogenesis intestinal epithelial cell migration positive regulation of ERK1 and ERK2 cascade positive regulation of glucose import in response to insulin stimulus fibroblast growth factor receptor signaling pathway regulation of phosphatidylinositol 3-kinase signaling cerebellar cortex formation platelet activation T cell costimulation phosphatidylinositol-3-phosphate biosynthetic process regulation of protein complex assembly phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling leukocyte migration Bergmann glial cell differentiation regulation of type I interferon-mediated signaling pathway
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