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  • SCN1B Antibodies

Alomone Labs, LTD

SCN1B (NaV beta 1) (extracellular) Polyclonal Antibody

View all (7) SCN1B antibodies

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Datasheet
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Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite SCN1B (NaV beta 1) (extracellular) Polyclonal Antibody

  • Antibody Testing Data (3)
SCN1B (NaV beta 1) (extracellular) Antibody in Immunocytochemistry (ICC/IF)
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SCN1B (NaV beta 1) (extracellular) Antibody in Immunocytochemistry (ICC/IF)
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SCN1B (NaV beta 1) (extracellular) Antibody (ASC-041-200UL) in ICC/IF

Expression of NaV beta 1in differentiated rat PC12 cells - Cell surface detection of NaV beta 1in live and intact differentiated rat PC12 cells. PC12 differentiation was induced byNative mouse NGF 2.5S protein (>95%) (#N-100). A, C. Merge of NaV beta 1staining using Anti-SCN1B (NaV beta 1) (extracellular) Antibody (#ASC-041), (1:50), (red) with live cell imaging. B, D. Merge of NaV beta 1staining (1:50), (r... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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SCN1B (NaV beta 1) (extracellular) Antibody in Immunocytochemistry (ICC/IF)
SCN1B (NaV beta 1) (extracellular) Antibody in Immunohistochemistry (IHC)
SCN1B (NaV beta 1) (extracellular) Antibody in Western Blot (WB)
SCN1B (NaV beta 1) (extracellular) Polyclonal Antibody

Product Details

ASC-041-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400
-

Immunohistochemistry (IHC)

Assay-dependent
-

Immunocytochemistry (ICC/IF)

1:50
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CKRRSETTAETFTE, corresponding to amino acid residues 43-56 of rat beta 1subunit of voltage-gated Na+channels, Extracellular, N-terminus
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.85 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel voltage-gated type 1 beta polypeptide; sodium channel voltage-gated type I beta polypeptide; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta polypeptide

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Gene Aliases: Scn1b

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UniProt ID: (Mouse) P97952, (Rat) Q00954

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Entrez Gene ID: (Mouse) 20266, (Rat) 29686

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Function(s)
voltage-gated ion channel activity voltage-gated sodium channel activity sodium channel activity protein binding sodium channel regulator activity sodium channel inhibitor activity voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential
Process(es)
regulation of sodium ion transport transport ion transport sodium ion transport axon guidance positive regulation of sodium ion transport positive regulation of neuron projection development neuronal action potential propagation corticospinal neuron axon guidance regulation of ion transmembrane transport sodium ion transmembrane transport locomotion response to pyrethroid membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane depolarization cardiac conduction cardiac muscle cell action potential involved in contraction membrane depolarization during cardiac muscle cell action potential membrane depolarization during Purkinje myocyte cell action potential regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transporter activity
It has to be done as per old AB suggested Products section.
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