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Invitrogen
Ricin alpha VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA0983)
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Product Details
MA5-54258
Species Reactivity
Host/Isotype
Expression System
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
RRID
Product Specific Information
Compatible with Direct ELISA
Target Information
Ricin toxin (RCA60), is a 60 kDa glycoprotein that consists of two chains, A and B, covalently linked by disulfide bond. The A chain acts as a glycosidase that removes an adenine residue from the 28S rRNA. The area from which the adenine is removed is essental for binding of elongation factors, destroying it leaves the ribosome inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, much faster than the cell can replace them, meaning that a single ricin A chain can kill a cell. The B chain binds to complex carbohydrates on the cell surface to facilitate entry of the A Chain into the cell. Without the B chain, the A chain has very low toxicity. Ricin is easily extracted from castor bean (Ricinus comunis), and the lethal dose for humans is very small. It is toxic when inhaled, ingested or injected and there is no known antidote, alhough a vaccine has been developed. Treatment is symptomatic and supportive, with long term organ damage likely in survivors. The ease of extraction and distribution makes it a potential candidate for bilogical warfare although it is less stable than other agents, such as anthrax.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
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