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Invitrogen
RPS10 Polyclonal Antibody
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Product Details
PA5-120968
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Positive test controls include: MCF7, HL-60, A-549, HT-29, NCI-H460, Mouse spleen, Mouse heart. The target is usually found in the following locations: Cytoplasm, Nucleus, nucleolus.
Immunogen sequence: MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEIV PATLRRSRPE TGRPRPKGLE GERPARLTRG EADRDTYRRS AVPPGADKKA EAGAGSATEF QFRGGFGRGR GQPPQ
Target Information
Ribosomes, the organelles that catalyze protein synthesis, are composed of a small subunit (40S) and a large subunit (60S) that consist of over 80 distinct ribosomal proteins. Mammalian ribosomal proteins are encoded by multigene families that contain processed pseudogenes and one functional intron-containing gene within their coding regions. Ribosomal Protein S10 (RPS10) is a 165 amino acid component of the small ribosomal 40S subunit. While generally found in the cytoplasm, RPS10 can localize to the granular component (GC) region of the nucleolus. For this to occur, methylation by PRMT5 is required as well as an interaction with NPS1. Defects in RPS10 are the cause of Diamond-Blackfan anemia type 9 (DBA9). It is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 40S ribosomal protein S10; RP11-375E1__A.4; Small ribosomal subunit protein eS10
Gene Aliases: 2210402A09Rik; DBA9; RPS10; S10
UniProt ID: (Human) P46783, (Mouse) P63325, (Rat) P63326
Entrez Gene ID: (Human) 6204, (Mouse) 67097, (Rat) 81773
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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