Invitrogen

RORA Polyclonal Antibody

View all (18) RORA antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-34159

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL
-
Product Specifications

Species Reactivity

Bat, Bovine, Dog, Horse, Human, Mouse, Non-human primate, Pig, Rabbit, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 20 amino acid peptide from ligand-binding domain of human ROR Alpha.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551512

Target Information

RORA is a receptor for retinoic acid belonging to the NR1 subfamily of nuclear hormone receptors with a nuclear receptor DNA binding domain. RORA binds either as a monomer or as a homodimer to the retinoic acid response element and thus regulates gene expression and also controls cell function. Though the exact function of RORA is yet unknown, it interacts with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, NM23-1, the product of a tumor metastasis suppressor candidate gene, CDK7, NCOA3 and NCOA6 coactivators. It is found to express in mesenchymal stem cells derived from bone marrow and are known to act by direct modulation of a bone matrix component. It is widely expressed in most of the tissues. Chromosomal aberrations involving RORA may be a cause of acute promyelocytic leukemia (APL).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Nuclear receptor ROR-alpha; Nuclear receptor RZR-alpha; Nuclear receptor subfamily 1 group F member 1; RAR-related orphan receptor A; RAR-related orphan receptor alpha; retinoic acid receptor-related orphan receptor alpha; retinoid-related orphan receptor alpha; Retinoid-related orphan receptor-alpha; ROR Alpha; ROR-alpha; Roralpha; thyroid hormone nuclear receptor alpha variant 4; transcription factor RZR-alpha

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Gene Aliases: 9530021D13Rik; BOS_10826; nmf267; NR1F1; ROR1; ROR2; ROR3; RORA; RZR-ALPHA; RZRA; sg; staggerer; tmgc26

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UniProt ID: (Human) P35398, (Mouse) P51448

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Entrez Gene ID: (Rabbit) 100357159, (Dog) 478328, (Bovine) 535597, (Human) 6095, (Rat) 300807, (Mouse) 19883

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding core promoter sequence-specific DNA binding transcription corepressor binding transcription coactivator binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding beta-catenin binding transcription factor binding oxysterol binding zinc ion binding sequence-specific DNA binding transcription factor activity, direct ligand regulated sequence-specific DNA binding metal ion binding
Process(es)
angiogenesis regulation of transcription, DNA-templated transcription initiation from RNA polymerase II promoter xenobiotic metabolic process nitric oxide biosynthetic process regulation of smoothened signaling pathway positive regulation of vascular endothelial growth factor production regulation of glucose metabolic process regulation of steroid metabolic process cerebellar Purkinje cell differentiation cerebellar granule cell precursor proliferation intracellular receptor signaling pathway circadian regulation of gene expression cellular response to sterol muscle cell differentiation positive regulation of circadian rhythm regulation of macrophage activation negative regulation of I-kappaB kinase/NF-kappaB signaling steroid hormone mediated signaling pathway negative regulation of fat cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter cGMP metabolic process negative regulation of inflammatory response regulation of transcription involved in cell fate commitment triglyceride homeostasis cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia T-helper 17 cell differentiation regulation of cholesterol homeostasis transcription, DNA-templated circadian rhythm regulation of circadian rhythm rhythmic process
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