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Invitrogen
RAP1GAP Polyclonal Antibody
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FIGURE: 1 / 5
RAP1GAP Antibody (PA5-106715) in IHC (P)
Product Details
PA5-106715
Species Reactivity
Host/Isotype
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Type
Immunogen
Conjugate
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Purification
Storage buffer
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RRID
Product Specific Information
Antibody detects endogenous levels of total RAP1GAP.
Target Information
Rap1GAP specifically stimulates GTP hydrolytic activity of the monomeric G protein Rap1. Physical interaction between G alpha z, a member of the Gi family of trimeric G proteins, and Rap1GAP blocks the ability of regulators of G protein signaling to stimulate GTP hydrolysis of the alpha subunit, and also attenuates the ability of activated G alpha z to inhibit adenylyl cyclase. Rap1GAP is expressed in the brain, kidney and pancreas and may act as a signal integrator to coordinate and/or integrate Gz signaling and Rap1 signaling in cells. A novel isoform of Rapl GTPase-activating protein, designated Rap1GAPII, binds specifically to G alpha z. Stimulation of the Gi-coupled M2 Muscarinic receptor translocates Rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1, resulting in the activation of ERK/MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: ARPP-90; Rap1 GTPase-activating protein 1; Rap1, GTPase-activating protein 1; Rap1GAP
Gene Aliases: 1300019I11Rik; 2310004O14Rik; AI427470; ARPP-90; KIAA0474; RAP1GA1; RAP1GAP; RAP1GAP1; RAP1GAPII; RAPGAP
UniProt ID: (Human) P47736, (Mouse) A2ALS5
Entrez Gene ID: (Human) 5909, (Mouse) 110351, (Rat) 313644
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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