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Proteintech
RAD18 Polyclonal Antibody
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Product Details
18333-1-AP
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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Product Specific Information
This antibody is specific to RAD18.
Immunogen sequence: MDSLAESRW PPGLAVMKTI DDLLRCGICF EYFNIAMIIP QCSHNYCSLC IRKFLSYKTQ CPTCCVTVTE PDLKNNRILD ELVKSLNFAR NHLLQFALES PAKSPASSSS KNLAVKVYTP VASRQSLKQG SRLMDNFLIR EMSGSTSELL IKENKSKFSP QKEASPAAKT KETRSVEEIA PDPSEAKRPE PPSTSTLKQV TKVDCPVCGV NIPESHINKH LDSCLSREEK KESLRSSVHK RKPLPKTVYN LLSDRDLKKK LKEHGLSIQG NKQQLIKRHQ EFVHMYNAQC DALHPKSAAE IVQEIENIEK TRMRLEASKL NESVMVFTKD QTEKEIDEIH SKYRKKHKSE FQLLVDQARK GYKKIAGMSQ KTVTITKEDE STEKLSSVCM GQEDNMTSVT NHFSQSKLDS PEELEPDREE DSSSCIDIQE VLSSSESDSC NSSSSDIIRD LLEEEEAWEA SHKNDLQDTE ISPRQNRRTR AAESAEIEPR NKRNRN (1-495 aa encoded by B C001302)
Target Information
Human Rad18 (hRad18) is homologue of the S. pombe Rad18 (3,4). In yeast, Rad6 and Rad18 play a crucial role in post-replication repair functions in gap-filling of a daughter strand on replication of damaged DNA (2). Furthermore, Rad6-Rad18 interaction is thought to be critical at an early step during lesion bypass in yeast. In vivo, Rad18 protein forms a tight complex with Rad6 through a conserved ring-finger motif (3,4). It has been suggested that Rad18-Rad6 complex binds to the damaged sites by the single-stranded DNA binding property of Rad 18. This is followed by degradation of the stalled components of DNA replication by ubiquitin-conjugating enzyme activity of Rad6 (1). The human Rad18 maps on chromosome 3p24-25, the region which is often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene codes for a protein of 495 amino acids with a predicted molecular weight of 56 kDa. The human Rad18 is ubiquitously expressed in various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; mRAD18Sc; post-replication repair protein RAD18SC; postreplication repair protein hRAD18p; Postreplication repair protein RAD18; RAD18 E3 ubiquitin protein ligase; RAD18 homolog; RAD18, S. cerevisiae, homolog; RING finger protein 73; RING-type E3 ubiquitin transferase RAD18
Gene Aliases: 2810024C04Rik; RAD18; Rad18sc; RNF73
UniProt ID: (Human) Q9NS91, (Mouse) Q9QXK2
Entrez Gene ID: (Human) 56852, (Mouse) 58186, (Rat) 362412
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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