Invitrogen

Prothrombin Fragment 1/2 Monoclonal Antibody (D1)

Name: Prothrombin Fragment 1\/2 Monoclonal Antibody (D1)
Brand: Invitrogen
SKU: MA5-50943

View all (2) Prothrombin Fragment 1/2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Immunogen image

Prothrombin Fragment 1/2 Monoclonal Antibody (D1)

Antibody Testing Data (6)

Prothrombin Fragment 1/2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

Prothrombin Fragment 1/2 Antibody (MA5-50943) in ICC/IF

Immunocytochemistry analysis of Prothrombin Fragment 1/2 in HepG2 cells. Samples were incubated with Prothrombin Fragment 1/2 monoclonal antibody (Product # MA5-50943) using a dilution of 30 µg/mL followed by FITC-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 2 µg/mL.

Prothrombin Fragment 1/2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Prothrombin Fragment 1/2 Antibody in Western Blot (WB)

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Product Details

MA5-50943

Applications

Tested Dilution

Publications

Western Blot (WB)

0.01-2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

5-20 µg/mL

Immunocytochemistry (ICC/IF)

5-20 µg/mL

Product Specifications

Species Reactivity

Human, Pig, Rat

Host/Isotype

Mouse / IgG2b, kappa

Class

Monoclonal

Type

Antibody

Clone

Immunogen

Recombinant Human F1+2 protein, Ala44-Arg327 (Accession #P00734)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.05% Proclin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_3094024

Target Information

Prothrombin Fragment 1/2 is a protein fragment that is produced by the cleavage of prothrombin, a blood clotting protein. It is a small peptide consisting of the first half of the prothrombin molecule and is involved in the formation of blood clots. Prothrombin Fragment 1/2 is used as a biomarker for the diagnosis and monitoring of various blood clotting disorders.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: coagulation factor 2; Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; Prothrombin fragment 1+2; prothrombin fragment 1.2; Prothrombin fragment F1+2; prothrombin fragment F1.2; serine protease; thrombin

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Gene Aliases: F2; PT; RPRGL2; THPH1

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UniProt ID: (Pig) Q19AZ8, (Human) P00734

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Entrez Gene ID: (Pig) 100144442, (Rat) 29251, (Human) 2147

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Function(s)

serine-type endopeptidase activity receptor binding calcium ion binding peptidase activity thrombospondin receptor activity protein binding growth factor activity

Process(es)

positive regulation of protein phosphorylation proteolysis acute-phase response cell surface receptor signaling pathway blood coagulation positive regulation of cell proliferation regulation of cell shape response to wounding regulation of gene expression positive regulation of phosphatidylinositol 3-kinase signaling response to inactivity platelet activation positive regulation of blood coagulation positive regulation of cell growth positive regulation of collagen biosynthetic process wound healing fibrinolysis negative regulation of proteolysis negative regulation of astrocyte differentiation positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration cellular response to mechanical stimulus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of reactive oxygen species metabolic process signal peptide processing ER to Golgi vesicle-mediated transport multicellular organism development blood coagulation, intrinsic pathway negative regulation of platelet activation peptidyl-glutamic acid carboxylation regulation of blood coagulation cellular protein metabolic process leukocyte migration negative regulation of fibrinolysis

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Prothrombin Fragment 1/2 Monoclonal Antibody (D1)

Prothrombin Fragment 1/2 Antibody (MA5-50943) in ICC/IF

Product Details

MA5-50943

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Target Information

References (0)

Bioinformatics

Performance Guarantee

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