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  • Prohibitin Antibodies

NeoBiotechnologies

Prohibitin (Mitochondrial Marker) Monoclonal Antibody (PHB/3228)

View all (53) Prohibitin antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Cite Prohibitin (Mitochondrial Marker) Monoclonal Antibody (PHB/3228)

  • Antibody Testing Data (5)
Prohibitin (Mitochondrial Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Prohibitin (Mitochondrial Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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Prohibitin (Mitochondrial Marker) Antibody (5245-MSM8-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human Liver stained with Prohibitin Mouse Monoclonal Antibody (PHB/3228). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Prohibitin (Mitochondrial Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Prohibitin (Mitochondrial Marker) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Prohibitin (Mitochondrial Marker) Antibody in Western Blot (WB)
Prohibitin (Mitochondrial Marker) Antibody in Peptide array (ARRAY)
Prohibitin (Mitochondrial Marker) Antibody in SDS-PAGE (SDS-PAGE)
Prohibitin (Mitochondrial Marker) Monoclonal Antibody (PHB/3228)

Product Details

5245-MSM8-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

PHB/3228

Immunogen

Recombinant human PHB protein fragment (aa167-261).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Wet ice

Target Information

Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; Prohibitin 1

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Gene Aliases: HEL-215; HEL-S-54e; PHB; PHB1

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UniProt ID: (Human) P35232

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Entrez Gene ID: (Human) 5245

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding complement component C3a binding complement component C3b binding protein binding protein C-terminus binding enzyme binding proteinase activated receptor binding histone deacetylase binding transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter osteoblast differentiation regulation of transcription, DNA-templated mitochondrion organization signal transduction negative regulation of cell proliferation negative regulation of transcription by competitive promoter binding histone deacetylation negative regulation of cell growth negative regulation of protein catabolic process regulation of apoptotic process positive regulation of G-protein coupled receptor protein signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of complement activation protein stabilization progesterone receptor signaling pathway negative regulation of androgen receptor signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade cellular response to interleukin-6 DNA biosynthetic process negative regulation of glucocorticoid receptor signaling pathway
It has to be done as per old AB suggested Products section.
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