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Invitrogen
Podoplanin Monoclonal Antibody (NZ-1.2)
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FIGURE: 1 / 8
Podoplanin Antibody (MA5-16267) in ICC/IF
Product Details
MA5-16267
Species Reactivity
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Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Aggrus; CTA-520D8.1; E11; Glycoprotein 36; Glycoprotein 38; glycoprotein, 36-KD; Gp36; Gp38; hT1alpha-1; hT1alpha-2; lung type I cell membrane associated glycoprotein; lung type-I cell membrane-associated glycoprotein (T1A-2); OTS-8; OTTHUMP00000009640; OTTHUMP00000044504; PA2.26 antigen; PDPN; Podoplanin; RP23-348F1.2; T1-alpha; T1A; Transmembrane glycoprotein E11
Gene Aliases: AGGRUS; GP36; Gp38; GP40; HT1A-1; OTS-8; OTS8; PA2.26; PDPN; PSEC0003; PSEC0025; RANDAM-2; T1-alpha; T1A; T1A-2; T1A2; T1alpha; TI1A
UniProt ID: (Human) Q86YL7, (Mouse) Q62011
Entrez Gene ID: (Human) 10630, (Mouse) 14726
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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