Invitrogen

Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235) Polyclonal Antibody

15 Published Figures
38 References
View all (88) c-Met antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-c-Met (Tyr1230, Tyr1234, Tyr1235) Polyclonal Antibody

Product Details

44-888G

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 19 publications 19 publications

Immunohistochemistry (IHC)

-
View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

-
View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

-
View 2 publications 2 publications

Immunoprecipitation (IP)

-
View 1 publication 1 publication

peptide-ELISA (pep-ELISA)

Assay-dependent
-

Affinity Purification (AP)

-
- -

Miscellaneous PubMed (MISC)

-
View 6 publications 6 publications
Product Specifications

Species Reactivity

Human, Mouse

Published species

Dog, Hamster, Human, Mouse, Virus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human c-Met that contains tyrosines 1230, 1234 and 1235. The sequence is conserved in mouse and rat.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Antigen affinity chromatography

Storage buffer

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

Contains

0.05% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533787

Target Information

MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. There interactions lead to the activation of signaling cascades including RAS-ERK, PI3, kinase-AKT, and PLCgamma-PKC. MET plays a role in embryonic development including gastrulation, development of muscles and neurons, angiogenesis, and kidney formation. It also plays a role in adults including wound healing, organ regeneration, and tissue remodeling. MET has been linked to cancers including gastric, renal, and breast; therefore, making it a target for cancer therapeutics and diagnostic testing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: cMet; EC 2.7.10.1; Hepatocyte growth factor receptor; HGF receptor; HGF-SF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; oncogene MET; Proto-oncogene c-Met; sc MET; Scatter factor receptor; SF receptor; soluble c met; Tyrosine-protein kinase Met

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Gene Aliases: AI838057; AUTS9; c-Met; DFNB97; HGF; HGFR; MET; Par4; RCCP2

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UniProt ID: (Human) P08581

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Entrez Gene ID: (Human) 4233, (Mouse) 17295

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Function(s)
protein tyrosine kinase activity hepatocyte growth factor-activated receptor activity protein binding ATP binding protein phosphatase binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity beta-catenin binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups protein complex binding phospholipase binding phosphatidylinositol 3-kinase binding protein heterodimerization activity
Process(es)
endothelial cell morphogenesis signal transduction cell surface receptor signaling pathway cell proliferation negative regulation of autophagy peptidyl-tyrosine phosphorylation positive regulation of transcription from RNA polymerase II promoter hepatocyte growth factor receptor signaling pathway branching morphogenesis of an epithelial tube positive chemotaxis semaphorin-plexin signaling pathway negative regulation of hydrogen peroxide-mediated programmed cell death positive regulation of endothelial cell chemotaxis negative regulation of transcription from RNA polymerase II promoter activation of MAPK activity neuron migration liver development placenta development protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway brain development muscle organ development skeletal muscle tissue development positive regulation of gene expression positive regulation of peptidyl-threonine phosphorylation negative regulation of peptidyl-threonine phosphorylation positive regulation of glucose transport positive regulation of neuron projection development muscle cell migration myotube differentiation phosphorylation sperm motility adult behavior positive regulation of peptidyl-serine phosphorylation glucose homeostasis positive regulation of DNA replication positive regulation of mitotic nuclear division protein autophosphorylation positive regulation of dendrite morphogenesis modulation of synaptic transmission myoblast proliferation excitatory postsynaptic potential regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
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