Invitrogen

Phospho-VEGF Receptor 1 (Tyr1333) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-VEGF Receptor 1 (Tyr1333) Polyclonal Antibody

Product Details

PA5-40252

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

1:100-1:300
-

ELISA (ELISA)

1:40,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human Flt-1 around the phosphorylation site of Y1333.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609309

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Embryonic receptor kinase 2; FLT; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; Vascular permeability factor receptor; VEGF R1; VEGFR-1

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Gene Aliases: AI323757; Emrk2; FLT; FLT-1; FLT1; FRT; sFlt1; VEGFR-1; VEGFR1

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UniProt ID: (Human) P17948, (Mouse) P35969

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Entrez Gene ID: (Human) 2321, (Mouse) 14254, (Rat) 54251

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Function(s)
transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups identical protein binding receptor signaling protein tyrosine kinase activity
Process(es)
angiogenesis patterning of blood vessels response to hypoxia sprouting angiogenesis monocyte chemotaxis protein phosphorylation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation cell migration peptidyl-tyrosine phosphorylation cell differentiation positive regulation of cell migration positive regulation of vascular endothelial growth factor receptor signaling pathway cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway vascular endothelial growth factor signaling pathway positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis embryonic morphogenesis positive regulation of hematopoietic progenitor cell differentiation activation of MAPKK activity regulation of smooth muscle contraction positive regulation of cell proliferation signal transduction by protein phosphorylation intracellular receptor signaling pathway positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation
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