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Invitrogen
Phospho-SLP76 (Tyr145) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-SLP76 (Tyr145) Antibody (PA5-105201) in WB
Product Details
PA5-105201
Species Reactivity
Host/Isotype
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Immunogen
Conjugate
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RRID
Product Specific Information
Antibody detects endogenous levels of SLP76 only when phosphorylated at Tyr145.
Target Information
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 76 kDa tyrosine phosphoprotein; Lymphocyte cytosolic protein 2; lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa); lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD); SH2 domain-containing leukocyte protein of 76 kDa; SH2 domain-containing leukocyte protein of 76kD; SLP-76 tyrosine phosphoprotein; SLP76
Gene Aliases: AI323664; BB161688; LCP2; SLP-76; SLP76; twm
UniProt ID: (Human) Q13094, (Mouse) Q60787
Entrez Gene ID: (Human) 3937, (Mouse) 16822, (Rat) 155918
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