Invitrogen

Phospho-NFkB p105 (Ser923) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-NFkB p105 (Ser923) Polyclonal Antibody

Product Details

PA5-105757

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NFKB1(Accession P19838), corresponding to amino acid residues around phosphorylated Ser923.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2817156

Product Specific Information

Antibody detects endogenous levels of NF kappaB p105/p50 only when phosphorylated at Ser923.

Target Information

NF-kB is a nuclear transcription factor activated by various extra and intracellular stimuli such as cytokines, UV radiation, stress, in injury, and by bacterial and viral products. It is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. NFKB1 (p50), a 50KDa functional sub-unit of NF-kB, is a member of Rel protein family. It is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers or heterodimerizes with p65, forming the functional NF-kB factor. NFKB1 (p50) directs the nuclear translocation of NF-kB and is instrumental in its DNA-bidning. Pathological role of NF-kB has been suggested in AIDS, hematogenic cancer cell metastasis and rheumatoid arthritis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DNA-binding factor KBF1; EBP-1; NF kappaB1; NF KB; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB p50; NF-kappabeta; NF-kB p105; nuclear factor; nuclear factor kappa b; nuclear factor kappa-B DNA binding subunit; nuclear factor kappaB p50; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB

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Gene Aliases: CVID12; EBP-1; KBF1; NF-kappa-B; NF-kappaB; NF-kappaB1; NF-kB; NF-KB1; NFkappaB; NFKB-p105; NFKB-p50; NFKB1; p105; p50; p50/p105

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UniProt ID: (Human) P19838, (Mouse) P25799, (Rat) Q63369

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Entrez Gene ID: (Human) 4790, (Mouse) 18033, (Rat) 81736

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Function(s)
regulatory region DNA binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding heat shock protein binding identical protein binding protein homodimerization activity actinin binding transcription regulatory region DNA binding protein heterodimerization activity RNA polymerase II transcription factor activity, sequence-specific DNA binding DNA binding double-stranded DNA binding sequence-specific DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter negative regulation of cytokine production transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process inflammatory response response to oxidative stress signal transduction I-kappaB kinase/NF-kappaB signaling negative regulation of calcidiol 1-monooxygenase activity response to cytokine response to muscle stretch NIK/NF-kappaB signaling negative regulation of apoptotic process negative regulation of interleukin-12 biosynthetic process innate immune response negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter lymph node development negative regulation of inflammatory response cellular response to lipopolysaccharide cellular response to nicotine cellular response to interleukin-6 cellular response to dsRNA cellular response to peptide hormone stimulus positive regulation of canonical Wnt signaling pathway positive regulation of hyaluronan biosynthetic process positive regulation of miRNA metabolic process response to bacterium response to copper ion cellular response to mechanical stimulus cellular response to interleukin-1 stimulatory C-type lectin receptor signaling pathway positive regulation of macrophage derived foam cell differentiation positive regulation of lipid storage negative regulation of vitamin D biosynthetic process membrane protein intracellular domain proteolysis negative regulation of cellular protein metabolic process negative regulation of cholesterol transport positive regulation of type I interferon production Fc-epsilon receptor signaling pathway T cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity stress-activated MAPK cascade cellular response to carbohydrate stimulus cellular response to tumor necrosis factor cellular response to diterpene cellular response to glucoside cellular response to brain-derived neurotrophic factor stimulus
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