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Invitrogen
Phospho-FOXO4 (Thr451) Polyclonal Antibody
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FIGURE: 1 / 19
Phospho-FOXO4 (Thr451) Antibody (PA5-104944) in ICC/IF
Product Details
PA5-104944
Species Reactivity
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Conjugate
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Product Specific Information
Antibody detects endogenous levels of FOXO4 only when phosphorylated at Threonine 451.
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Translocated To, 7) and is a member of the O class of forkhead/ winged helix family of transcription factors along with FOXO1, FOXO3 and FOXO6. FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. FOXO4 binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1. However, the activation of another downstream target of the Insulin/IGF1 pathway, Akt, leads to phosphorylation of FOXO4 on specific Ser/Thr residues. This phosphorylation mediates binding of FOXO4 to 14-3-3 and eventual exit of FOXO4 from the nucleus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Afxh; AFXzeta; Fork head domain transcription factor AFX1; Forkhead box protein O4; forkhead protein; FOXO4b; MGC120490; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; OTTHUMP00000023497
Gene Aliases: AFX; AFX1; Afxh; Fkhr3; FOXO4; MLLT7; RGD1561201
UniProt ID: (Human) P98177, (Mouse) Q9WVH3
Entrez Gene ID: (Human) 4303, (Rat) 302415, (Mouse) 54601
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