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Invitrogen
Phospho-Claudin 5 (Thr207 ) Polyclonal Antibody
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Phospho-Claudin 5 (Thr207 ) Antibody (PA5-105058) in IHC (P)
Product Details
PA5-105058
Species Reactivity
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Immunogen
Conjugate
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Product Specific Information
Antibody detects endogenous levels of Claudin 5 only when phosphorylated at Thr207 .
Target Information
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. Alternatively spliced transcript variants encoding different isoforms have been found.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Brain endothelial cell clone 1 protein; Claudin-5; Lung-specific membrane protein; TMDVCF; Transmembrane protein deleted in VCFS; transmembrane protein deleted in velocardiofacial syndrome
Gene Aliases: AI854493; AWAL; BEC1; CLDN5; CPETRL1; MBEC1; TMVCF
UniProt ID: (Human) O00501, (Rat) Q9JKD6, (Mouse) O54942
Entrez Gene ID: (Human) 7122, (Rat) 65131, (Mouse) 12741
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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