Invitrogen

Phospho-CaMKII alpha/delta (Thr286) Polyclonal Antibody

View all (2) CaMKII alpha/delta antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-CaMKII alpha/delta (Thr286) Polyclonal Antibody

Product Details

PA5-105043

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CAMK2A(Accession Q9UQM7), corresponding to amino acid residues around phosphorylated Thr286.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816516

Product Specific Information

Antibody detects endogenous levels of CaMK2 alpha/delta only when phosphorylated at Threonine 286.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alpha CaM kinase II; alpha-CaMKII; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II alpha subunit; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II alpha subunit; CaM kinase II delta subunit; CaM kinase II subunit alpha; CaM kinase II subunit delta; CaM-kinase II alpha chain; CaM-kinase II delta chain; CaMK II; CaMK-2 delta; CaMK-2a; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit delta; CaMK2 delta; CaMK2- delta; CaMK2-a; CaMKIINalpha

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Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CaMK II; CAMK1; Camk2; CAMK2A; CAMK2D; CAMKA; CAMKD; Camki; CaMKII; KIAA0968; Kiaa4163; mKIAA0968; PK2CDD; PKCCD; R74975; RATCAMKI

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UniProt ID: (Human) Q9UQM7, (Human) Q13557, (Mouse) P11798, (Rat) P11275, (Rat) P15791, (Mouse) Q6PHZ2

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Entrez Gene ID: (Human) 815, (Human) 817, (Mouse) 12322, (Rat) 25400, (Rat) 24246, (Mouse) 108058

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Function(s)
protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding kinase activity glutamate receptor binding protein homodimerization activity sodium channel inhibitor activity titin binding ion channel binding nitric-oxide synthase binding nucleotide binding protein kinase activity transferase activity transferase activity, transferring phosphorus-containing groups GTPase activating protein binding
Process(es)
G1/S transition of mitotic cell cycle MAPK cascade regulation of cell growth response to hypoxia regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport regulation of heart contraction regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of GTPase activity protein autophosphorylation positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity interferon-gamma-mediated signaling pathway regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cellular response to heat regulation of histone deacetylase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity response to ischemia phosphorylation ionotropic glutamate receptor signaling pathway angiotensin-activated signaling pathway regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity positive regulation of NF-kappaB transcription factor activity positive regulation of calcium ion transport regulation of mitochondrial membrane permeability involved in apoptotic process regulation of sodium ion transport cardiac muscle contraction Wnt signaling pathway, calcium modulating pathway
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