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Invitrogen
Phospho-CHK1 (Ser345) Monoclonal Antibody (S.48.4)
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FIGURE: 1 / 8
Phospho-CHK1 (Ser345) Antibody (MA5-15145) in ICC/IF
Product Details
MA5-15145
Species Reactivity
Published species
Host/Isotype
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Type
Clone
Immunogen
Conjugate
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RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cell cycle checkpoint kinase; checkpoint kinase 1 homolog; Checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27 homolog; Serine/threonine-protein kinase Chk1; Synoviolin
Gene Aliases: C85740; CHEK1; CHK1; rad27
UniProt ID: (Human) O14757, (Rat) Q91ZN7, (Mouse) O35280
Entrez Gene ID: (Human) 1111, (Rat) 140583, (Mouse) 12649
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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