Invitrogen

Phospho-C/EBP alpha (Ser193) Polyclonal Antibody

2 Published Figures
3 References
View all (24) C/EBP alpha antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Phospho-C/EBP alpha (Ser193) Polyclonal Antibody

Product Details

PA5-37342

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 3 publications 3 publications
Product Specifications

Species Reactivity

Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic phosphopeptide derived from mouse C/EBP alpha around the phosphorylation site of Serine 193
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554017

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 37 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: C EBP; C/EBP alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; OTTHUMP00000220269

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Gene Aliases: C/ebpalpha; CBF-A; Cebp; Cebpa; DBPCEP

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UniProt ID: (Mouse) P53566, (Rat) P05554

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Entrez Gene ID: (Mouse) 12606, (Rat) 24252

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase I regulatory region DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription coactivator activity protein binding transcription factor binding kinase binding protein domain specific binding protein complex binding protein homodimerization activity histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity HMG box domain binding
Process(es)
urea cycle negative regulation of transcription from RNA polymerase II promoter liver development embryonic placenta development transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase I promoter transcription from RNA polymerase II promoter mitochondrion organization Notch signaling pathway multicellular organism development cholesterol metabolic process negative regulation of cell proliferation cytokine-mediated signaling pathway myeloid cell differentiation macrophage differentiation lung development granulocyte differentiation regulation of cell proliferation glucose homeostasis fat cell differentiation positive regulation of fat cell differentiation positive regulation of osteoblast differentiation negative regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter cell maturation inner ear development white fat cell differentiation brown fat cell differentiation lipid homeostasis cellular response to lithium ion cellular response to organic cyclic compound acute-phase response response to nutrient cell differentiation organ regeneration response to vitamin B2 response to glucocorticoid
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