Invitrogen

Phospho-Btk (Tyr344) Polyclonal Antibody

View all (72) BTK antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
Phospho-Btk (Tyr344) Polyclonal Antibody

Product Details

PA5-105620

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BTK(Accession Q06187), corresponding to amino acid residues around phosphorylated Tyr344.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817048

Product Specific Information

Antibody detects endogenous levels of BTK only when phosphorylated at Tyr344.

Target Information

Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It has recently been shown to interact with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9. The TLRs are critical molecules in both the innate and adaptive immunity and can recognize diverse microbial pathogens. BTK has also been shown to interact with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting that BTK is involved in lipopolysaccharide signal transduction.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: agammaglobulinaemia tyrosine kinase; Agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton's tyrosine kinase; dominant-negative kinase-deficient Brutons tyrosine kinase; Kinase EMB; MGC126261; MGC126262; OTTHUMP00000023677; RP1-164F3.2; truncated Bruton agammaglobulinemia tyrosine kinase; Tyrosine-protein kinase BTK; Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB); tyrosine-protein kinase BTK isoform (lacking exon 13 to 17); tyrosine-protein kinase BTK isoform (lacking exon 14); X-linked immune deficiency

View more View less

Gene Aliases: AGMX1; AI528679; AT; ATK; BPK; BTK; IMD1; PSCTK1; xid; XLA

View more View less

UniProt ID: (Human) Q06187, (Mouse) P35991

View more View less

Entrez Gene ID: (Human) 695, (Rat) 367901, (Mouse) 12229

View more View less

Function(s)
protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding phosphatidylinositol-3,4,5-trisphosphate binding identical protein binding metal ion binding nucleotide binding protein kinase activity lipid binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
adaptive immune response histamine secretion by mast cell protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway I-kappaB kinase/NF-kappaB signaling response to organic substance peptidyl-tyrosine phosphorylation cell differentiation cellular response to reactive oxygen species peptidyl-tyrosine autophosphorylation regulation of cell proliferation innate immune response protein autophosphorylation cell maturation T cell receptor signaling pathway B cell receptor signaling pathway cellular response to molecule of fungal origin negative regulation of cytokine production regulation of B cell cytokine production MyD88-dependent toll-like receptor signaling pathway regulation of B cell apoptotic process transcription, DNA-templated mesoderm development calcium-mediated signaling intracellular signal transduction Fc-epsilon receptor signaling pathway B cell activation positive regulation of B cell differentiation positive regulation of NF-kappaB transcription factor activity apoptotic signaling pathway immune system process regulation of transcription, DNA-templated apoptotic process phosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support