Proteintech

PRMT6 Polyclonal Antibody

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View all (27) PRMT6 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
PRMT6 Polyclonal Antibody

Product Details

15395-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 9 publications 9 publications

Immunohistochemistry (IHC)

-
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:500
View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg
-
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

PRMT6 Fusion Protein Ag7592 (1-316 aa encoded by BC002729)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Western blot analysis using this antibody detected a major band around 42 kDa in Hela cells.

Immunogen sequence: MIADRVRTD AYRLGILRNW AALRGKTVLD VGAGTGILSI FCAQAGARRV YAVEASAIWQ QAREVVRFNG LEDRVHVLPG PVETVELPEQ VDAIVSEWMG YGLLHESMLS SVLHARTKWL KEGGLLLPAS AELFIAPISD QMLEWRLGFW SQVKQHYGVD MSCLEGFATR CLMGHSEIVV QGLSGEDVLA RPQRFAQLEL SRAGLEQELE AGVGGRFRCS CYGSAPMHGF AIWFQVTFPG GESEKPLVLS TSPFHPATHW KQALLYLNEP VQVEQDTDVS GEITLLPSRD NPRRLRVLLR YKVGDQEEKT KDFAMED (1-316 aa encoded by BC002729)

Target Information

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: FLJ10559; FLJ51477; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; PRMT-6; Protein arginine N-methyltransferase 6

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Gene Aliases: AW124876; BB233495; HRMT1L6; PRMT6

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UniProt ID: (Human) Q96LA8, (Mouse) Q6NZB1

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Entrez Gene ID: (Human) 55170, (Mouse) 99890

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Function(s)
chromatin binding protein binding histone-arginine N-methyltransferase activity protein-arginine N-methyltransferase activity protein-arginine omega-N monomethyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity histone methyltransferase activity histone binding histone methyltransferase activity (H4-R3 specific) histone methyltransferase activity (H3-R2 specific) histone methyltransferase activity (H2A-R3 specific) rRNA (adenine-N6,N6-)-dimethyltransferase activity protein C-terminal carboxyl O-methyltransferase activity tRNA (guanine-N2-)-methyltransferase activity methyltransferase activity C-methyltransferase activity N-methyltransferase activity O-methyltransferase activity S-methyltransferase activity RNA methyltransferase activity mRNA methyltransferase activity tRNA methyltransferase activity protein methyltransferase activity 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity rRNA methyltransferase activity rRNA (uridine-2'-O-)-methyltransferase activity rRNA (adenine-N6-)-methyltransferase activity DNA-methyltransferase activity tRNA (guanine-N1-)-methyltransferase activity rRNA (cytosine-C5-)-methyltransferase activity selenocysteine methyltransferase activity arginine N-methyltransferase activity lysine N-methyltransferase activity protein-lysine N-methyltransferase activity tRNA (uracil) methyltransferase activity tRNA (guanine) methyltransferase activity tRNA (adenine) methyltransferase activity tRNA (cytosine) methyltransferase activity tRNA (cytosine-5-)-methyltransferase activity tRNA (adenine-N1-)-methyltransferase activity rRNA (adenine) methyltransferase activity rRNA (cytosine) methyltransferase activity rRNA (guanine) methyltransferase activity rRNA (uridine) methyltransferase activity transferase activity protein C-terminal leucine carboxyl O-methyltransferase activity 1-phenanthrol methyltransferase activity protein-arginine N5-methyltransferase activity methylarsonite methyltransferase activity dimethylarsinite methyltransferase activity 4,5-dihydroxybenzo(a)pyrene methyltransferase activity 1-hydroxypyrene methyltransferase activity 1-hydroxy-6-methoxypyrene methyltransferase activity demethylmenaquinone methyltransferase activity cobalt-precorrin-6B C5-methyltransferase activity cobalt-precorrin-7 C15-methyltransferase activity cobalt-precorrin-5B C1-methyltransferase activity cobalt-precorrin-3 C17-methyltransferase activity dimethylamine methyltransferase activity hydroxyneurosporene-O-methyltransferase activity tRNA (adenine-57, 58-N(1)-) methyltransferase activity methylamine-specific methylcobalamin:coenzyme M methyltransferase activity trimethylamine methyltransferase activity methanol-specific methylcobalamin:coenzyme M methyltransferase activity monomethylamine methyltransferase activity P-methyltransferase activity Se-methyltransferase activity 2-phytyl-1,4-naphthoquinone methyltransferase activity tRNA (uracil-2'-O-)-methyltransferase activity tRNA (cytosine-2'-O-)-methyltransferase activity phosphomethylethanolamine N-methyltransferase activity tRNA (cytosine-3-)-methyltransferase activity rRNA (cytosine-2'-O-)-methyltransferase activity rRNA (cytosine-N4-)-methyltransferase activity trihydroxyferuloyl spermidine O-methyltransferase activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter DNA repair transcription, DNA-templated regulation of transcription, DNA-templated protein methylation cellular response to DNA damage stimulus cell growth chromatin modification histone methylation peptidyl-arginine methylation, to asymmetrical-dimethyl arginine methylation histone arginine methylation histone H3-R2 methylation peptidyl-arginine N-methylation histone H4-R3 methylation negative regulation of transcription, DNA-templated cellular senescence base-excision repair viral process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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