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NeoBiotechnologies

PRDM1/BLIMP-1 Monoclonal Antibody (PCRP-PRDM1-2B9)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite PRDM1/BLIMP-1 Monoclonal Antibody (PCRP-PRDM1-2B9)

  • Antibody Testing Data (2)
PRDM1/BLIMP-1 Antibody in Immunocytochemistry (ICC/IF)
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PRDM1/BLIMP-1 Antibody in Immunocytochemistry (ICC/IF)
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PRDM1/BLIMP-1 Antibody (639-MSM1-P1) in ICC/IF

Immunofluorescence Analysis of PFA-fixed HeLa cells stained using PRDM1 Mouse Monoclonal Antibody (PCRP-PRDM1-2B9) followed by goat anti-mouse IgG-CF488 (green). CF640R phalloidin (red). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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PRDM1/BLIMP-1 Antibody in Immunocytochemistry (ICC/IF)
PRDM1/BLIMP-1 Antibody in Flow Cytometry (Flow)
PRDM1/BLIMP-1 Monoclonal Antibody (PCRP-PRDM1-2B9)

Product Details

639-MSM1-P1

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

2-4 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/mL
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

PCRP-PRDM1-2B9

Immunogen

Recombinant full-length human PRDM1 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:HeLa or MCF-7 cells.

Cellular Location: Nucleus. Cytoplasm.

Target Information

Blimp-1 (B lymphocyte maturation protein-1) is a nuclear protein with five zinc fingers in its carboxy terminus. It is a transcriptional repressor that is both required and sufficient to trigger terminal differentiation of B lymphocytes and monocyte/macrophages. Blimp-1 is expressed in, and may be required for terminally differentiated epithelial cells, retinal neurons and other lineage cells. It has also been implicated in the repression of beta-interferon (IFN-beta) and c-myc gene expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-lymphocyte-induced maturation protein 1; Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP 1; BLIMP-1; MGC118922; MGC118923; MGC118924; MGC118925; OTTHUMP00000016918; OTTHUMP00000202173; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI BF1; PRDI-BF1; PRDI-binding factor-1; RP1-134E15.1

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Gene Aliases: BLIMP1; PRDI-BF1; PRDM1

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UniProt ID: (Human) O75626

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Entrez Gene ID: (Human) 639

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein binding methyltransferase activity histone deacetylase binding metal ion binding promoter-specific chromatin binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter morphogenesis of a branching structure maternal placenta development heart valve development ventricular septum development transcription, DNA-templated germ cell development post-embryonic development positive regulation of gene expression negative regulation of B cell proliferation negative regulation of lipopolysaccharide-mediated signaling pathway methylation regulation of natural killer cell differentiation regulation of extrathymic T cell differentiation aorta development eye photoreceptor cell development cell fate commitment positive regulation of B cell differentiation artery morphogenesis regulation of NK T cell differentiation intestinal epithelial cell development trophoblast giant cell differentiation coronary vasculature development sebum secreting cell proliferation
It has to be done as per old AB suggested Products section.
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