OriGene

PPARD Monoclonal Antibody (OTI4D10), TrueMAB™

View all (24) PPAR delta antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
PPARD Monoclonal Antibody (OTI4D10), TrueMAB™

Product Details

CF811238

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI4D10

Immunogen

Human recombinant protein fragment corresponding to amino acids 1-244 of human PPARD produced in E.coli.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta

View more View less

Gene Aliases: FAAR; NR1C2; NUC-1; NUC1; NUCI; NUCII; PPAR-beta; PPAR-delta; PPAR[b]; PPARB; Pparb/d; PPARD; PPARdelta

View more View less

UniProt ID: (Human) Q03181, (Mouse) P35396

View more View less

Entrez Gene ID: (Human) 5467, (Rat) 25682, (Mouse) 19015

View more View less

Function(s)
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding transcription factor binding drug binding zinc ion binding lipid binding sequence-specific DNA binding protein heterodimerization activity NF-kappaB binding linoleic acid binding fatty acid binding enzyme activator activity prostacyclin receptor activity metal ion binding retinoid X receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter placenta development proteoglycan metabolic process lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process heart development embryo implantation cell proliferation positive regulation of cell proliferation axon ensheathment phospholipid biosynthetic process mRNA transcription response to glucose response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling response to activity negative regulation of smooth muscle cell migration fatty acid transport fatty acid oxidation cell differentiation negative regulation of cell growth intracellular receptor signaling pathway cell-substrate adhesion positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A wound healing regulation of cell proliferation negative regulation of apoptotic process steroid hormone mediated signaling pathway keratinocyte proliferation regulation of fat cell differentiation positive regulation of epidermis development positive regulation of transcription, DNA-templated positive regulation of vasodilation decidualization negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration adipose tissue development cellular response to hypoxia apoptotic signaling pathway glucose metabolic process generation of precursor metabolites and energy regulation of transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter apoptotic process cholesterol metabolic process fatty acid catabolic process regulation of skeletal muscle satellite cell proliferation glucose transport positive regulation of skeletal muscle tissue regeneration positive regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated cellular response to lipopolysaccharide negative regulation of pri-miRNA transcription from RNA polymerase II promoter positive regulation of myoblast proliferation transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter G-protein coupled receptor signaling pathway epidermis development cellular process anagen positive regulation of catalytic activity regulation of insulin secretion
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support