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PITX2 Polyclonal Antibody

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View all (16) PITX2 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
PITX2 Polyclonal Antibody

Product Details

OSP00157W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-

Miscellaneous PubMed (MISC)

-
View 2 publications 2 publications
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 20-70 of mouse Pituitary homeobox 2 conjugated to an immunogenic carrier protein was used as the antigen
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of MQ water. Centrifuge to remove any insoluble material.

Specificity of this antibody: PITX2.

Target Information

Pilx2 is a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. It plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this protein are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ALL1-responsive protein ARP1; Bicoid-related homeobox protein 1; BRX1 homeoprotein; Homeobox protein PITX2; Orthodenticle-like homeobox 2; Paired-like homeodomain transcription factor 2; paired-like homeodomain transcription factor Munc 30; Pituitary homeobox 2; S a 1 glycoprotein; S a1glycoprotein; S alpha 1 glycoprotein; S α 1 glycoprotein; S α1glycoprotein; Solurshin

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Gene Aliases: 9430085M16Rik; Arp1; Brx1; Brx1b; Munc30; Otlx2; Pitx2; Ptx2; Rgs; Rieg

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UniProt ID: (Mouse) P97474

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Entrez Gene ID: (Mouse) 18741

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding RNA polymerase II activating transcription factor binding RNA polymerase II transcription coactivator activity transcriptional repressor activity, RNA polymerase II transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding chromatin DNA binding identical protein binding protein homodimerization activity sequence-specific DNA binding phosphoprotein binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter patterning of blood vessels vasculogenesis in utero embryonic development neuron migration extraocular skeletal muscle development atrioventricular valve development cardiac neural crest cell migration involved in outflow tract morphogenesis pulmonary myocardium development regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter multicellular organism development determination of left/right symmetry heart development skeletal muscle tissue development myoblast fusion anatomical structure morphogenesis organ morphogenesis Wnt signaling pathway subthalamic nucleus development hypothalamus cell migration pituitary gland development lung development regulation of cell migration embryonic camera-type eye development embryonic hindlimb morphogenesis vascular smooth muscle cell differentiation deltoid tuberosity development regulation of cell proliferation odontogenesis camera-type eye development positive regulation of DNA binding positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter spleen development embryonic digestive tract morphogenesis cardiac muscle tissue development cardiac muscle cell differentiation atrial cardiac muscle tissue morphogenesis ventricular cardiac muscle cell development digestive system development ventricular septum morphogenesis left lung morphogenesis pulmonary vein morphogenesis superior vena cava morphogenesis endodermal digestive tract morphogenesis iris morphogenesis cell proliferation involved in outflow tract morphogenesis left/right axis specification positive regulation of myoblast proliferation
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