OriGene

PIK3CG Monoclonal Antibody (OTI2B1), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
PIK3CG Monoclonal Antibody (OTI2B1), TrueMAB™

Product Details

CF505221

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:150
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

OTI2B1

Immunogen

Full length human recombinant protein of human PIK3CG produced in HEK293T cell.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)

Target Information

PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; PI3-kinase subunit gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG

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Gene Aliases: p110gamma; p120-PI3K; PI3CG; PI3K; PI3Kgamma; PIK3; PIK3CG

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UniProt ID: (Human) P48736

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Entrez Gene ID: (Human) 5294

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Function(s)
protein kinase activity protein serine/threonine kinase activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity ephrin receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Process(es)
angiogenesis cytokine production adaptive immune response dendritic cell chemotaxis positive regulation of acute inflammatory response respiratory burst involved in defense response protein phosphorylation phosphatidylinositol biosynthetic process endocytosis inflammatory response G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration T cell chemotaxis negative regulation of triglyceride catabolic process phosphatidylinositol 3-kinase signaling platelet activation neutrophil chemotaxis secretory granule localization regulation of cell adhesion mediated by integrin natural killer cell chemotaxis phosphatidylinositol-3-phosphate biosynthetic process T cell proliferation T cell activation mast cell degranulation positive regulation of MAP kinase activity innate immune response phosphatidylinositol phosphorylation positive regulation of protein kinase B signaling negative regulation of cardiac muscle contraction platelet aggregation cellular response to cAMP neutrophil extravasation hepatocyte apoptotic process regulation of calcium ion transmembrane transport negative regulation of fibroblast apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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