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Proteintech
PIAS3 Polyclonal Antibody
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Product Details
13486-1-AP
Species Reactivity
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Immunogen
Conjugate
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Product Specific Information
The PIAS3 antibody detects PIAS3 (68 kDa) as well as its sumoylated form (85 kDa) in some normal mouse tissues, breast and brain tumor cell lines.
Immunogen sequence: VRQLTAGTL LQKLRAKGIR NPDHSRALIK EKLTADPDSE VATTSLRVSL MCPLGKMRLT VPCRALTCAH LQSFDAALYL QMNEKKPTWT CPVCDKKAPY ESLIIDGLFM EILSSCSDCD EIQFMEDGSW CPMKPKKEAS EVCPPPGYGL DGLQYSPVQG GDPSENKKKV EVIDLTIESS SDEEDLPPTK KHCSVTSAAI PALPGSKGVL TSGHQPSSVL RSPAMGTLGG DFLSSLPLHE YPPAFPLGAD IQGLDLFSFL QTESQHYGPS VITSLDEQDA LGHFFQYRGT PSHFLGPLAP TLGSSHCSAT PAPPPGRVSS IVAPGGALRE GHGGPLPSGP SLTGCRSDII SLD (277-628 aa encoded by BC030556)
Target Information
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS3. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS3 binds specifically to STAT3 following the stimulation of STAT3. Increased expression of PIAS3 has been observed in several human cancers, including lung, breast, and brain tumors, but not in anaplastic lymphoma kinase-positive T/null-cell lymphomas, indicating that PIAS3 plays multiple roles in different tissue and cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; KChAP; potassium channel regulatory protein KChAP; Potassium channel-associated protein; Protein inhibitor of activated STAT protein 3; protein inhibitor of activated STAT, 3; zinc finger, MIZ-type containing 5
Gene Aliases: PIAS3; Pias3l; ZMIZ5
UniProt ID: (Human) Q9Y6X2, (Mouse) O54714, (Rat) O70260
Entrez Gene ID: (Human) 10401, (Mouse) 229615, (Rat) 83614
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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