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Invitrogen
PHOX2A Polyclonal Antibody
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Product Details
PA5-34381
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
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RRID
Product Specific Information
A suggested positive control is rat brain tissue lysate.
PA5-34381 can be used with blocking peptide PEP-1424.
Target Information
PHOX2A and PHOX2B (Paired mesoderm homeobox protein) are closely related, paired-homeodomain transcription factors that function as determinants of the noradrenergic phenotype during embryogenesis. PHOX2 proteins are crucial for the regulation of endogenous hydroxylases in neural crest cells and promote sympathetic neuron generation. Human PHOX2B contains one DNA binding homeobox domain and is required for the differentiation of all central and nonperipheral noradrenergic centers in the brain. In contrast, PHOX2A controls only the differentiation of the main noradrenergic center of the brain. Regulation of PHOX2 may have therapeutic utility in aging or disorders involving degeneration of noradrenergic neurons.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: aristaless homeobox gene homolog; aristaless homeobox homolog; Aristaless homeobox protein homolog; arix homeodomain protein; ARIX1 homeodomain protein; paired mesoderm homeobox 2a; Paired mesoderm homeobox protein 2A; Paired-like homeobox 2A; PHOX2A homeodomain protein
Gene Aliases: ARIX; CFEOM2; FEOM2; NCAM2; Phox2; PHOX2A; Pmx2; PMX2A
UniProt ID: (Human) O14813, (Mouse) Q62066, (Rat) Q62782
Entrez Gene ID: (Human) 401, (Mouse) 11859, (Rat) 116648
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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