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Proteintech
PEX5 Polyclonal Antibody
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Product Details
12545-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
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Product Specific Information
This antibody recognizes endogenous PEX5, which migrates with an apparent molecular mass of 80 kDa.
Immunogen sequence: EGDLPNAVL LFEAAVQQDP KHMEAWQYLG TTQAENEQEL LAISALRRCL ELKPDNQTAL MALAVSFTNE SLQRQACETL RDWLRYTPAY AHLVTPAEEG AGGAGLGPSK RILGSLLSDS LFLEVKELFL AAVRLDPTSI DPDVQCGLGV LFNLSGEYDK AVDCFTAALS VRPNDYLLWN KLGATLANGN QSEEAVAAYR RALELQPGYI RSRYNLGISC INLGAHREAV EHFLEALNMQ RKSRGPRGEG GAMSENIWST LRLALSMLGQ SDAYGAADAR DLSTLLTMFG LPQ (340-639 aa encoded by BC010621)
Target Information
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: peroxin 5; Peroxin-5; peroxisomal biogenesis factor 5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; PXR1P
Gene Aliases: AW212715; ESTM1; PBD2A; PBD2B; PEX5; Pex5_predicted; PTS1-BP; PTS1R; PXR1; RCDP5; X83306
UniProt ID: (Human) P50542, (Mouse) O09012, (Rat) Q2M2R8
Entrez Gene ID: (Human) 5830, (Mouse) 19305, (Rat) 312703
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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