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Proteintech
PDE6A Polyclonal Antibody
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Product Details
21200-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MGEVTAEEV EKFLDSNIGF AKQYYNLHYR AKLISDLLGA KEAAVDFSNY HSPSSMEESE IIFDLLRDFQ ENLQTEKCIF NVMKKLCFLL Q (1-90 aa encoded by BC035909)
Target Information
This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cGMP phosphodiesterase alpha; cGMP phosphodiesterase alpha subunit; GMP-PDE alpha; PDE V-B1; phosphodiesterase 6A, cGMP-specific, rod, alpha; Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; rod photoreceptor cGMP phosphodiesterase alpha subunit
Gene Aliases: CGPR-A; nmf282; PDE6A; PDEA; RP43
UniProt ID: (Human) P16499
Entrez Gene ID: (Human) 5145, (Mouse) 225600, (Rat) 307401
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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